Lipopolysaccaride-induced neutrophilic inflammation in the lungs differs with age

Yoko Ito, Tomoko Betsuyaku, Yasuyuki Nasuhara, Masaharu Nishimura

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)


In aged humans and animals, lung injuries are generally more serious and prolonged. From a kinetic perspective, the authors thus assessed whether lung expression of proinflammatory cytokines were altered with age following intratracheal lipopolysaccharide (LPS) challenge in mice. Tumor necrosis factor-α, interleukin-1β, macrophage inflammatory protein-1α, macrophage inflammatory protein-2, and keratinocyte-derived chemokine were significantly higher in 65-week-old mice along with sustained neutrophilia when compared to 11-week-old mice at 72 hours, but not at earlier time points. The authors concluded that the degree of LPS-induced neutrohilic inflammation and the expression of these cytokines differ with age at later phases of acute lung injury.

Original languageEnglish
Pages (from-to)375-384
Number of pages10
JournalExperimental Lung Research
Issue number7
Publication statusPublished - 2007 Sept


  • Acute lung injury
  • Age
  • IL-1β
  • LPS
  • TNF-α

ASJC Scopus subject areas

  • Molecular Biology
  • Pulmonary and Respiratory Medicine
  • Clinical Biochemistry


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