Liquid chromatography-mass spectrometry for the determination of medetomidine and other anaesthetics in plasma

Hideko Kanazawa; Yoshiko Nagata; Yoshikazu Matsushima; Nobuharu Takai; Hidefumi Uchiyama; Ryohei Nishimura; Akira Takeuchi

doi:10.1016/0021-9673(93)80524-C

Liquid chromatography-mass spectrometry for the determination of medetomidine and other anaesthetics in plasma

Hideko Kanazawa
, Yoshiko Nagata
, Yoshikazu Matsushima
, Nobuharu Takai
, Hidefumi Uchiyama
, Ryohei Nishimura
, Akira Takeuchi

School of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

A liquid chromatographic-atmospheric pressure chemical ionization mass spectrometric method is presented for the simultaneous determination of medetomidine and other anaesthetic drugs in solutions and dog plasma. The drugs examined were flumazenil, butorphanol, atropine, ketamine, xylazine, medetomidine, atipamezole and midazolam. The separation was carried out on a reversed-phase column using methanol-0.1 M ammonium acetate (3:2) as eluent.

Original language	English
Pages (from-to)	215-220
Number of pages	6
Journal	Journal of Chromatography A
Volume	631
Issue number	1-2
DOIs	https://doi.org/10.1016/0021-9673(93)80524-C
Publication status	Published - 1993 Feb 12

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry
Organic Chemistry

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10.1016/0021-9673(93)80524-C

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title = "Liquid chromatography-mass spectrometry for the determination of medetomidine and other anaesthetics in plasma",

abstract = "A liquid chromatographic-atmospheric pressure chemical ionization mass spectrometric method is presented for the simultaneous determination of medetomidine and other anaesthetic drugs in solutions and dog plasma. The drugs examined were flumazenil, butorphanol, atropine, ketamine, xylazine, medetomidine, atipamezole and midazolam. The separation was carried out on a reversed-phase column using methanol-0.1 M ammonium acetate (3:2) as eluent.",

author = "Hideko Kanazawa and Yoshiko Nagata and Yoshikazu Matsushima and Nobuharu Takai and Hidefumi Uchiyama and Ryohei Nishimura and Akira Takeuchi",

note = "Funding Information: This work was supportedi n part by the Science ResearchP romotion Fund of the Japan Private School Promotion Foundation.",

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doi = "10.1016/0021-9673(93)80524-C",

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T1 - Liquid chromatography-mass spectrometry for the determination of medetomidine and other anaesthetics in plasma

AU - Kanazawa, Hideko

AU - Nagata, Yoshiko

AU - Matsushima, Yoshikazu

AU - Takai, Nobuharu

AU - Uchiyama, Hidefumi

AU - Nishimura, Ryohei

AU - Takeuchi, Akira

N1 - Funding Information: This work was supportedi n part by the Science ResearchP romotion Fund of the Japan Private School Promotion Foundation.

PY - 1993/2/12

Y1 - 1993/2/12

N2 - A liquid chromatographic-atmospheric pressure chemical ionization mass spectrometric method is presented for the simultaneous determination of medetomidine and other anaesthetic drugs in solutions and dog plasma. The drugs examined were flumazenil, butorphanol, atropine, ketamine, xylazine, medetomidine, atipamezole and midazolam. The separation was carried out on a reversed-phase column using methanol-0.1 M ammonium acetate (3:2) as eluent.

AB - A liquid chromatographic-atmospheric pressure chemical ionization mass spectrometric method is presented for the simultaneous determination of medetomidine and other anaesthetic drugs in solutions and dog plasma. The drugs examined were flumazenil, butorphanol, atropine, ketamine, xylazine, medetomidine, atipamezole and midazolam. The separation was carried out on a reversed-phase column using methanol-0.1 M ammonium acetate (3:2) as eluent.

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UR - https://www.scopus.com/pages/publications/0027459157#tab=citedBy

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DO - 10.1016/0021-9673(93)80524-C

M3 - Article

C2 - 8450013

AN - SCOPUS:0027459157

SN - 0021-9673

VL - 631

SP - 215

EP - 220

JO - Journal of Chromatography A

JF - Journal of Chromatography A

IS - 1-2

ER -

Liquid chromatography-mass spectrometry for the determination of medetomidine and other anaesthetics in plasma

Abstract

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