TY - JOUR
T1 - Lissoclibadins 4-7, polysulfur aromatic alkaloids from the Indonesian ascidian Lissoclinum cf. badium
AU - Nakazawa, Takahiro
AU - Xu, Jingzhon
AU - Nishikawa, Teruaki
AU - Oda, Taiko
AU - Fujita, Ayako
AU - Ukai, Kazuyo
AU - Mangindaan, Remy E.P.
AU - Rotinsulu, Henki
AU - Kobayashi, Hisayoshi
AU - Namikoshi, Michio
PY - 2007/3/1
Y1 - 2007/3/1
N2 - Four new polysulfur aromatic alkaloids, lissoclibadins 4 (1), 5 (2), 6 (3), and 7 (4), were isolated from the ascidian Lissoclinum cf. badium collected in Indonesia, together with seven known alkaloids, lissoclibadins 1 (5), 2 (6), and 3 (7), lissoclinotoxins E (8) and F (9), 3,4-dimemoxy-6-(2′-N,N- dimethylaminoethyl)-5-(methylthio)benzotrithiane (10), and N,N-dimethyl-5- (memylthio)varacin (11). Compounds 1-11 were isolated from the ascidian collected in March (wet season), while 5-11 have been obtained previously from the organism collected in September (dry season) at the same site. The structures of the new compounds were assigned on the basis of their spectroscopic data. Lissoclibadins 4-7 (1-4) inhibited the colony formation of Chinese hamster V79 cells with EC50 values of 0.71, 0.06, 0.06, and 0.17 μM, respectively. Compounds 1-4 showed also weak antimicrobial activity against Staphylococcus aureus, Escherichia coli, and Saccharomyces cerevisiae.
AB - Four new polysulfur aromatic alkaloids, lissoclibadins 4 (1), 5 (2), 6 (3), and 7 (4), were isolated from the ascidian Lissoclinum cf. badium collected in Indonesia, together with seven known alkaloids, lissoclibadins 1 (5), 2 (6), and 3 (7), lissoclinotoxins E (8) and F (9), 3,4-dimemoxy-6-(2′-N,N- dimethylaminoethyl)-5-(methylthio)benzotrithiane (10), and N,N-dimethyl-5- (memylthio)varacin (11). Compounds 1-11 were isolated from the ascidian collected in March (wet season), while 5-11 have been obtained previously from the organism collected in September (dry season) at the same site. The structures of the new compounds were assigned on the basis of their spectroscopic data. Lissoclibadins 4-7 (1-4) inhibited the colony formation of Chinese hamster V79 cells with EC50 values of 0.71, 0.06, 0.06, and 0.17 μM, respectively. Compounds 1-4 showed also weak antimicrobial activity against Staphylococcus aureus, Escherichia coli, and Saccharomyces cerevisiae.
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U2 - 10.1021/np060593c
DO - 10.1021/np060593c
M3 - Article
C2 - 17269824
AN - SCOPUS:34247092858
SN - 0163-3864
VL - 70
SP - 439
EP - 442
JO - Journal of Natural Products
JF - Journal of Natural Products
IS - 3
ER -