TY - JOUR
T1 - Lissoclibadins 8-14, polysulfur dopamine-derived alkaloids from the colonial ascidian Lissoclinum cf. badium
AU - Wang, Weifang
AU - Takahashi, Ohgi
AU - Oda, Taiko
AU - Nakazawa, Takahiro
AU - Ukai, Kazuyo
AU - Mangindaan, Remy E.P.
AU - Rotinsulu, Henki
AU - Wewengkang, Defny S.
AU - Kobayashi, Hisayoshi
AU - Tsukamoto, Sachiko
AU - Namikoshi, Michio
N1 - Funding Information:
This work was supported in part by Grant-in-Aid for Scientific Research (18032033 and 21603012) and for Scientific Research on Priority Areas (No. 17035029) from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan.
PY - 2009/11/14
Y1 - 2009/11/14
N2 - Seven new polysulfur alkaloids, lissoclibadins 8 (1)-14 (7), were isolated from an ascidian, Lissoclinum cf. badium, collected in Indonesia. The structures were assigned on the basis of their spectroscopic data and computational modeling study. Lissoclibadin 8 (1) had four identical dopamine-derived units, and this is the first instance of a tetramer. Lissoclibadin 9 (2) was the second example of trimers next to lissoclibadin 1 (8). Lissoclibadins 10 (3)-12 (5) were symmetric dimers, and 13 (6) had a dopamine and ethyl units connected by sulfide and disulfide bonds. Lissoclibadin 14 (7) was a varacin-type monomer. These compounds inhibited the colony formation of Chinese hamster V79 cells and cell proliferation of murine leukemia L1210 cells.
AB - Seven new polysulfur alkaloids, lissoclibadins 8 (1)-14 (7), were isolated from an ascidian, Lissoclinum cf. badium, collected in Indonesia. The structures were assigned on the basis of their spectroscopic data and computational modeling study. Lissoclibadin 8 (1) had four identical dopamine-derived units, and this is the first instance of a tetramer. Lissoclibadin 9 (2) was the second example of trimers next to lissoclibadin 1 (8). Lissoclibadins 10 (3)-12 (5) were symmetric dimers, and 13 (6) had a dopamine and ethyl units connected by sulfide and disulfide bonds. Lissoclibadin 14 (7) was a varacin-type monomer. These compounds inhibited the colony formation of Chinese hamster V79 cells and cell proliferation of murine leukemia L1210 cells.
KW - Cytotoxicity
KW - L1210
KW - Polysulfur alkaloid
KW - Structure assignment
KW - Tunicate
KW - V79
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U2 - 10.1016/j.tet.2009.09.056
DO - 10.1016/j.tet.2009.09.056
M3 - Article
AN - SCOPUS:70349792234
SN - 0040-4020
VL - 65
SP - 9598
EP - 9603
JO - Tetrahedron
JF - Tetrahedron
IS - 46
ER -