Localization of α-tocopherol transfer protein in rat brain

Akihiro Hosomi, Kaoru Goto, Hisatake Kondo, Takeshi Iwatsubo, Takanori Yokota, Masako Ogawa, Makoto Arita, Junken Aoki, Hiroyuki Arai, Keizo Inoue

Research output: Contribution to journalArticlepeer-review

94 Citations (Scopus)


Vitamin E (α-tocopherol) is a fat-soluble antioxidant that is transported by plasma lipoproteins in the body. α-Tocopherol transfer protein (α-TTP), which was identified as a product of the causative gene for familial isolated vitamin E (FIVE) deficiency, is a cytosolic liver protein which plays an important role in the efficient circulation of plasma vitamin E in the body. In the present study, we detected the message for α-TTP at low levels in some rat tissues including brain, spleen, lung and kidney. In the brain, the α-TTP transcript was detected predominantly in the cerebellar cortex, as revealed by in situ hybridization histochemistry. In the cerebellar cortex, clusters of the hybridization signal were aligned with the Purkinje cell layer, although the signal was not detected in the Purkinje cells, but in the small cells around the Purkinje cells. This distribution pattern strongly suggests that the message for α-TTP is expressed in the Bergmann glial cells. Combined with the previous observation that there was severe Purkinje cell loss in patients with FIVE deficiency, the present data suggest that vitamin E is supplied to the Purkinje cells from the surrounding Bergmann glial cells with the help of α-TTP.

Original languageEnglish
Pages (from-to)159-162
Number of pages4
JournalNeuroscience Letters
Issue number3
Publication statusPublished - 1998 Nov 13
Externally publishedYes


  • Familial isolated vitamin E deficiency
  • Vitamin E
  • α-Tocopherol transfer protein

ASJC Scopus subject areas

  • General Neuroscience


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