Localized recurrence of acute lymphoblastic leukemia-L3 in the tonsil after 3-years' remission

Rie Yamazaki, Nobuyuki Takayama, Yasuhiro Hamano, Takehiko Mori, Shinichiro Okamoto, Yasuo Ikeda

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Recurrence of Burkitt's lymphoma (BL)/acute lymphoblastic leukemia (ALL)-L3 after a long-term remission is very rare. We herein report on a case of BL/ALL-L3 indicating solitary recurrence in the tonsil after a 3-year remission. A 50-year-old man was diagnosed as having Burkitt's type ALL-L3 with involvement of the stomach and abdominal lymph nodes. He was treated with intensive chemotherapy consisting of methotrexate and cyclophosphamide (ALL-BFM86 protocol), and a complete remission was achieved. After sustaining the remission for three years, a swelling of the right tonsil was observed, which was histologically diagnosed as Burkitt's lymphoma. No other organ involvement, including the bone marrow, was observed. The pattern of c-myc rearrangement of the tonsil demonstrated by southern blotting was identical to that of the bone marrow at initial presentation and the recurrence of primary ALL-L3/BL was thus confirmed. The patient was then treated with the ALL-BFM86 protocol and subsequently underwent high-dose chemoradiotherapy with autologous peripheral blood stem cell transplantation (PBSCT). He has now been in complete remission for more than 2 years after his PBSCT.

Original languageEnglish
Pages (from-to)1004-1008
Number of pages5
Journal[Rinshō ketsueki] The Japanese journal of clinical hematology
Issue number11
Publication statusPublished - 2002 Nov

ASJC Scopus subject areas

  • General Medicine


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