TY - JOUR
T1 - Loneliness inside of the brain
T2 - evidence from a large dataset of resting-state fMRI in young adult
AU - Brilliant T, Denilson
AU - Takeuchi, Hikaru
AU - Nouchi, Rui
AU - Yokoyama, Ryoichi
AU - Kotozaki, Yuka
AU - Nakagawa, Seishu
AU - Hanawa, Sugiko
AU - Sekiguchi, Atsushi
AU - Ikeda, Shigeyuki
AU - Sakaki, Kohei
AU - Kawata, Kelssy Hitomi dos Santos
AU - Nozawa, Takayuki
AU - Yokota, Susumu
AU - Magistro, Daniele
AU - Kawashima, Ryuta
N1 - Funding Information:
This study was supported by a Grant-in-Aid for Young Scientists (B) (KAKENHI 23700306), and a Grant-in-Aid for Young Scientists (A) (KAKENHI 25700012) from the Ministry of Education, Culture, Sports, Science, and Technology. We respectfully thank Teruo Hashimoto for his statistical analysis guidance, Yuki Yamada for operating the MRI scanner, Haruka Nouchi for conducting the psychological tests, all other assistants for helping with the experiments and the study, the study participants, and all our other colleagues at the Institute of Development, Ageing and Cancer (IDAC), Tohoku University for their support.
Funding Information:
This study was supported by a Grant-in-Aid for Young Scientists (B) (KAKENHI 23700306), and a Grant-in-Aid for Young Scientists (A) (KAKENHI 25700012) from the Ministry of Education, Culture, Sports, Science, and Technology. We respectfully thank Teruo Hashimoto for his statistical analysis guidance, Yuki Yamada for operating the MRI scanner, Haruka Nouchi for conducting the psychological tests, all other assistants for helping with the experiments and the study, the study participants, and all our other colleagues at the Institute of Development, Ageing and Cancer (IDAC), Tohoku University for their support.
Publisher Copyright:
© 2022, The Author(s).
PY - 2022/12
Y1 - 2022/12
N2 - Although loneliness itself is a natural emotion, prolonged loneliness is detrimental to human health. Despite its detrimental effect, few loneliness-related neuroimaging studies have been published and some have limitations on the sample size number. This study aims to find the difference in resting-state functional connectivity associated with loneliness within a big sample size via the seed-based approach. Functional connectivity analysis was performed on a large cohort of young adults (N = 1336) using the seed-based functional connectivity approach to address the concern from previous studies. The analysis yielded statistically significant positive correlations between loneliness and functional connectivities between the inferior frontal gyrus and supplementary motor area, precentral gyrus, and superior parietal lobule. Additionally, the analysis replicated a finding from a previous study, which is increased functional connectivities between the inferior frontal gyrus and supplementary motor area. In conclusion, greater loneliness is reflected by stronger functional connectivity of the visual attention brain area.
AB - Although loneliness itself is a natural emotion, prolonged loneliness is detrimental to human health. Despite its detrimental effect, few loneliness-related neuroimaging studies have been published and some have limitations on the sample size number. This study aims to find the difference in resting-state functional connectivity associated with loneliness within a big sample size via the seed-based approach. Functional connectivity analysis was performed on a large cohort of young adults (N = 1336) using the seed-based functional connectivity approach to address the concern from previous studies. The analysis yielded statistically significant positive correlations between loneliness and functional connectivities between the inferior frontal gyrus and supplementary motor area, precentral gyrus, and superior parietal lobule. Additionally, the analysis replicated a finding from a previous study, which is increased functional connectivities between the inferior frontal gyrus and supplementary motor area. In conclusion, greater loneliness is reflected by stronger functional connectivity of the visual attention brain area.
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U2 - 10.1038/s41598-022-11724-5
DO - 10.1038/s41598-022-11724-5
M3 - Article
C2 - 35550564
AN - SCOPUS:85130635157
SN - 2045-2322
VL - 12
JO - Scientific reports
JF - Scientific reports
IS - 1
M1 - 7856
ER -
