Long-term adaptation of cerebral hemodynamic response to somatosensory stimulation during chronic hypoxia in awake mice

Hiroyuki Takuwa, Kazuto Masamoto, Kyoko Yamazaki, Hiroshi Kawaguchi, Yoko Ikoma, Yousuke Tajima, Takayuki Obata, Yutaka Tomita, Norihiro Suzuki, Iwao Kanno, Hiroshi Ito

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)


Effects of chronic hypoxia on hemodynamic response to sensory stimulation were investigated. Using laser-Doppler flowmetry, change in cerebral blood flow (CBF) was measured in awake mice, which were housed in a hypoxic chamber (8% O 2) for 1 month. The degree of increase in CBF evoked by sensory stimulation was gradually decreased over 1 month of chronic hypoxia. No significant reduction of increase in CBF induced by hypercapnia was observed during 1 month. Voltage-sensitive dye (VSD) imaging of the somatosensory cortex showed no significant decrease in neural activation over 1 month, indicating that the reduction of increase in CBF to sensory stimulation was not caused by cerebrovascular or neural dysfunction. The simulation study showed that, when effective diffusivity for oxygen in the capillary bed (D) value increases by chronic hypoxia due to an increase in capillary blood volume, an increase in the cerebral metabolic rate of oxygen utilization during neural activation can occur without any increase in CBF. Although previous study showed no direct effects of acute hypoxia on CBF response, our finding showed that hemodynamic response to neural activation could be modified in response to a change in their balance to energy demand using chronic hypoxia experiments.

Original languageEnglish
Pages (from-to)774-779
Number of pages6
JournalJournal of Cerebral Blood Flow and Metabolism
Issue number5
Publication statusPublished - 2013 May
Externally publishedYes


  • cerebral blood flow
  • energy metabolism
  • hemodynamics
  • microcirculation
  • neurovascular unit

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine


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