Long-term exercise down-regulates leptin receptor mRNA in the arcuate nucleus

Masaki Kimura; Naoto Tateishi; Tomoei Shiota; Fumihiko Yoshie; Hideki Yamauchi; Masato Suzuki; Toshiaki Shibasaki

doi:10.1097/00001756-200403220-00028

Long-term exercise down-regulates leptin receptor mRNA in the arcuate nucleus

Masaki Kimura, Naoto Tateishi, Tomoei Shiota, Fumihiko Yoshie, Hideki Yamauchi, Masato Suzuki, Toshiaki Shibasaki

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

The purpose of this study was to investigate the effects of exercise on blood leptin concentrations and expression of leptin receptor subtype-b (Ob-Rb) mRNA in the arcuate nucleus of hypothalamus (ARC). Male Wistar rats (26 weeks old) underwent regular wheel exercise for 12 weeks. The expression of Ob-Rb mRNA in the ARC decreased at the end of the study period despite reductions of abdominal fat-pad weight and serum leptin concentration. Serum 1,5-anhydroglucitol levels were higher in exercising rats, suggesting lower serum insulin levels in exercising rats. Our results suggested that 12-week wheel exercise reduced the expression of Ob-Rb mRNA in the ARC probably through improvement in insulin resistance.

Original language	English
Pages (from-to)	713-716
Number of pages	4
Journal	NeuroReport
Volume	15
Issue number	4
DOIs	https://doi.org/10.1097/00001756-200403220-00028
Publication status	Published - 2004 Mar 22

Keywords

ARC
Arcuate nucleus of hypothalamus
Chronic
Exercise
Leptin receptor
Long-term
Ob-Rb
Voluntary
mRNA

ASJC Scopus subject areas

Neuroscience(all)

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10.1097/00001756-200403220-00028

Cite this

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abstract = "The purpose of this study was to investigate the effects of exercise on blood leptin concentrations and expression of leptin receptor subtype-b (Ob-Rb) mRNA in the arcuate nucleus of hypothalamus (ARC). Male Wistar rats (26 weeks old) underwent regular wheel exercise for 12 weeks. The expression of Ob-Rb mRNA in the ARC decreased at the end of the study period despite reductions of abdominal fat-pad weight and serum leptin concentration. Serum 1,5-anhydroglucitol levels were higher in exercising rats, suggesting lower serum insulin levels in exercising rats. Our results suggested that 12-week wheel exercise reduced the expression of Ob-Rb mRNA in the ARC probably through improvement in insulin resistance.",

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AU - Kimura, Masaki

AU - Tateishi, Naoto

AU - Shiota, Tomoei

AU - Yoshie, Fumihiko

AU - Yamauchi, Hideki

AU - Suzuki, Masato

AU - Shibasaki, Toshiaki

PY - 2004/3/22

Y1 - 2004/3/22

N2 - The purpose of this study was to investigate the effects of exercise on blood leptin concentrations and expression of leptin receptor subtype-b (Ob-Rb) mRNA in the arcuate nucleus of hypothalamus (ARC). Male Wistar rats (26 weeks old) underwent regular wheel exercise for 12 weeks. The expression of Ob-Rb mRNA in the ARC decreased at the end of the study period despite reductions of abdominal fat-pad weight and serum leptin concentration. Serum 1,5-anhydroglucitol levels were higher in exercising rats, suggesting lower serum insulin levels in exercising rats. Our results suggested that 12-week wheel exercise reduced the expression of Ob-Rb mRNA in the ARC probably through improvement in insulin resistance.

AB - The purpose of this study was to investigate the effects of exercise on blood leptin concentrations and expression of leptin receptor subtype-b (Ob-Rb) mRNA in the arcuate nucleus of hypothalamus (ARC). Male Wistar rats (26 weeks old) underwent regular wheel exercise for 12 weeks. The expression of Ob-Rb mRNA in the ARC decreased at the end of the study period despite reductions of abdominal fat-pad weight and serum leptin concentration. Serum 1,5-anhydroglucitol levels were higher in exercising rats, suggesting lower serum insulin levels in exercising rats. Our results suggested that 12-week wheel exercise reduced the expression of Ob-Rb mRNA in the ARC probably through improvement in insulin resistance.

KW - ARC

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KW - Voluntary

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Long-term exercise down-regulates leptin receptor mRNA in the arcuate nucleus

Abstract

Keywords

ASJC Scopus subject areas

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