TY - JOUR
T1 - Long-term follow-up of dysphagia in adult patients with Duchenne muscular dystrophy
AU - Yamada, Yuka
AU - Kawakami, Michiyuki
AU - Wada, Ayako
AU - Fukui, Shogo
AU - Haruyama, Koshiro
AU - Otsuka, Tomoyoshi
AU - Liu, Meigen
N1 - Funding Information:
Acknowledgements, Funding sources: There was no funding source.
Publisher Copyright:
© 2018 European Paediatric Neurology Society
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2018/9
Y1 - 2018/9
N2 - Background: Dysphagia is a well-known dysfunction in patients with Duchenne muscular dystrophy (DMD), but long-term follow-up of this symptom has not been reported. The aims of this study were to investigate swallowing status, prospectively study the prognosis of swallowing function in adult patients with DMD over the course of 6 years, and to identify clinical factors related to prognosis. Methods: Participants were 81 patients with DMD. Swallowing status was assessed using the Neuromuscular Disease Swallowing Status Scale (NdSSS) every 2 years for 6 years. Results: NdSSS was related to age, functional ability assessed using the Swinyard staging and the status of ventilator dependence. Median NdSSS changed from 6 to 4, 4 and 3 over the 4 time points. Number of patients with tube feeding increased by 5–10% every 2 years. Initial NdSSS was a predictor of future swallowing status. Conclusion: Swallowing status declined over time in patients with adult DMD, with initial NdSSS as a predictor.
AB - Background: Dysphagia is a well-known dysfunction in patients with Duchenne muscular dystrophy (DMD), but long-term follow-up of this symptom has not been reported. The aims of this study were to investigate swallowing status, prospectively study the prognosis of swallowing function in adult patients with DMD over the course of 6 years, and to identify clinical factors related to prognosis. Methods: Participants were 81 patients with DMD. Swallowing status was assessed using the Neuromuscular Disease Swallowing Status Scale (NdSSS) every 2 years for 6 years. Results: NdSSS was related to age, functional ability assessed using the Swinyard staging and the status of ventilator dependence. Median NdSSS changed from 6 to 4, 4 and 3 over the 4 time points. Number of patients with tube feeding increased by 5–10% every 2 years. Initial NdSSS was a predictor of future swallowing status. Conclusion: Swallowing status declined over time in patients with adult DMD, with initial NdSSS as a predictor.
KW - Neuromuscular disease
KW - Predictor
KW - Prognosis
KW - Swallowing
UR - http://www.scopus.com/inward/record.url?scp=85049353759&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85049353759&partnerID=8YFLogxK
U2 - 10.1016/j.ejpn.2018.06.004
DO - 10.1016/j.ejpn.2018.06.004
M3 - Article
AN - SCOPUS:85049353759
SN - 1090-3798
VL - 22
SP - 786
EP - 790
JO - European Journal of Paediatric Neurology
JF - European Journal of Paediatric Neurology
IS - 5
ER -