Long-term survival after complete resection of non-small-cell lung cancer in patients with interstitial lung disease

Keigo Sekihara, Keiju Aokage, Tomonari Oki, Tomokazu Omori, Shinya Katsumata, Takuya Ueda, Tomohiro Miyoshi, Masaki Goto, Shoko Nakasone, Tomohiro Ichikawa, Tomoyuki Hishida, Junji Yoshida, Kakeru Hisakane, Koichi Goto, Masahiro Tsuboi

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)


OBJECTIVES: Patients with lung cancer and interstitial lung disease (ILD), usual interstitial pneumonia in particular, are known to have a poor outcome. The aim of this study was to evaluate the prognostic impact of ILD in patients with non-small-cell lung cancer. METHODS: A total of 2054 consecutive patients underwent complete resection of Stage IAIIIA non-small-cell lung cancer in our institution between January 2002 and March 2013. The presence of ILD was diagnosed and categorized based on high-resolution computed tomography images. Multivariate analysis was performed to identify the prognostic factors. RESULTS: There were 106 (5%) patients with ILD. There were significantly more patients who developed severe complications (P < 0.01) in the ILD group, with 4 (4%) patients developing acute exacerbation. Although the difference in postoperative mortality rate was marginal between the groups (P = 0.07), the 5-year overall survival and cancer-specific survival rates of the ILD patients were significantly worse than those of the non-ILD group (overall survival: 40.4% vs 72.0%, P < 0.01; cancer-specific survival 55.4% vs 78.6%, P < 0.01). The results of multivariate analysis showed that coexistence of ILD (hazard ratio 1.45; P = 0.01) was an independent, unfavourable prognostic factor. CONCLUSIONS: The presence of ILD led to a much poorer survival after complete resection of non-small-cell lung cancer.

Original languageEnglish
Pages (from-to)638-643
Number of pages6
JournalInteractive cardiovascular and thoracic surgery
Issue number4
Publication statusPublished - 2018 Apr 1
Externally publishedYes


  • Interstitial lung disease
  • Long-term survival
  • Non-small-cell lung cancer

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine


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