TY - JOUR
T1 - Long-term survival of a gastric neuroendocrine carcinoma patient with extra-regional lymph node metastases
AU - Ozawa, Yosuke
AU - Chiba, Naokazu
AU - Hikita, Kosuke
AU - Okihara, Masaaki
AU - Sano, Toru
AU - Tomita, Koichi
AU - Takano, Kiminori
AU - Kawachi, Shigeyuki
PY - 2017/4
Y1 - 2017/4
N2 - A 56-year-old man with advanced gastric tumor in the pyloric antrum had multiple lymph node metastases (lymph nodes #5, 6, 8, and 13), as revealed by abdominal computed tomography (CT). The patient was diagnosed with coexisting clinical Stage IIIA gastric cancer (cT2 [SS], cN2, cMO) with concomitant malignant lymphoma. Distal gastrectomy, D2 lymph node dissection, and resection of lymph node 3 were performed. Histopathological findings indicated that both the primary tumor and lymph node metastases were neuroendocrine carcinomas. Adjuvant chemotherapy with S-1 was administered; however, follow-up CT after 6 months revealed local recurrence around the celiac artery. Therefore, the chemotherapy regimen was changed to irinotecan and cisplatin. A clinical complete response was obtained after 6 chemotherapy courses and maintained for up to 45 months. The patient is alive at 60 months after the operation.
AB - A 56-year-old man with advanced gastric tumor in the pyloric antrum had multiple lymph node metastases (lymph nodes #5, 6, 8, and 13), as revealed by abdominal computed tomography (CT). The patient was diagnosed with coexisting clinical Stage IIIA gastric cancer (cT2 [SS], cN2, cMO) with concomitant malignant lymphoma. Distal gastrectomy, D2 lymph node dissection, and resection of lymph node 3 were performed. Histopathological findings indicated that both the primary tumor and lymph node metastases were neuroendocrine carcinomas. Adjuvant chemotherapy with S-1 was administered; however, follow-up CT after 6 months revealed local recurrence around the celiac artery. Therefore, the chemotherapy regimen was changed to irinotecan and cisplatin. A clinical complete response was obtained after 6 chemotherapy courses and maintained for up to 45 months. The patient is alive at 60 months after the operation.
KW - Cisplatin
KW - Gastric neuroendocrine cell carcinoma
KW - Irinotecan
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M3 - Article
C2 - 28428516
AN - SCOPUS:85021766676
SN - 0385-0684
VL - 44
SP - 333
EP - 336
JO - Japanese Journal of Cancer and Chemotherapy
JF - Japanese Journal of Cancer and Chemotherapy
IS - 4
ER -
