TY - JOUR
T1 - Longitudinal association of hypertension and diabetes mellitus with cognitive functioning in a general 70-year-old population
T2 - The SONIC study
AU - Ryuno, Hirochika
AU - Kamide, Kei
AU - Gondo, Yasuyuki
AU - Kabayama, Mai
AU - Oguro, Ryosuke
AU - Nakama, Chikako
AU - Yokoyama, Serina
AU - Nagasawa, Motonori
AU - Maeda-Hirao, Satomi
AU - Imaizumi, Yuki
AU - Takeya, Miyuki
AU - Yamamoto, Hiroko
AU - Takeda, Masao
AU - Takami, Yoichi
AU - Itoh, Norihisa
AU - Takeya, Yasushi
AU - Yamamoto, Koichi
AU - Sugimoto, Ken
AU - Nakagawa, Takeshi
AU - Yasumoto, Saori
AU - Ikebe, Kazunori
AU - Inagaki, Hiroki
AU - Masui, Yukie
AU - Takayama, Michiyo
AU - Arai, Yasumichi
AU - Ishizaki, Tatsuro
AU - Takahashi, Ryutaro
AU - Rakugi, Hiromi
N1 - Publisher Copyright:
© 2017 The Japanese Society of Hypertension. All rights reserved.
PY - 2017/7/1
Y1 - 2017/7/1
N2 - Both hypertension and diabetes in middle-aged individuals have been suggested to be predictive indicators of cognitive decline. However, the association of hypertension, diabetes and their combination with cognitive functioning is still controversial in older people. The purpose of this study was to investigate the association between cognitive decline and hypertension, diabetes, and their combination in 70-year-old people based on a 3-year longitudinal analysis. Four hundred and fifty-four people aged 70 (±1) years who participated in the Japanese longitudinal cohort study of Septuagenarians, Octogenarians and Nonagenarians Investigation with Centenarians (SONIC) were recruited randomly from a general population and were monitored for 3 years. The data, including most of the demographics, cognitive functioning measured by the Montreal Cognitive Assessment Japanese version (MoCA-J), blood pressure, blood chemistry and other medical histories, were collected at baseline and during the follow-up. The prevalence of hypertension noted in the follow-up survey was significantly higher than than noted at baseline. The mean MoCA-J score at follow-up was not significantly different from the score obtained at baseline. However, the participants with diabetes, especially combined with hypertension at baseline, had significantly lower MoCA-J scores than those without lifestyle-related diseases. The combination of hypertension and diabetes was still a significant risk factor for cognitive decline, considering the MoCA-J scores obtained during the follow-up after adjustments at baseline, relative to sex, body mass index, dyslipidemia, smoking, excessive alcohol intake, antihypertensive treatment and education level (β=-0.14; P<0.01). Our findings indicate that diabetes and the combination of hypertension and diabetes are clear risk factors for future cognitive decline in elderly individuals who are 70 years of age.
AB - Both hypertension and diabetes in middle-aged individuals have been suggested to be predictive indicators of cognitive decline. However, the association of hypertension, diabetes and their combination with cognitive functioning is still controversial in older people. The purpose of this study was to investigate the association between cognitive decline and hypertension, diabetes, and their combination in 70-year-old people based on a 3-year longitudinal analysis. Four hundred and fifty-four people aged 70 (±1) years who participated in the Japanese longitudinal cohort study of Septuagenarians, Octogenarians and Nonagenarians Investigation with Centenarians (SONIC) were recruited randomly from a general population and were monitored for 3 years. The data, including most of the demographics, cognitive functioning measured by the Montreal Cognitive Assessment Japanese version (MoCA-J), blood pressure, blood chemistry and other medical histories, were collected at baseline and during the follow-up. The prevalence of hypertension noted in the follow-up survey was significantly higher than than noted at baseline. The mean MoCA-J score at follow-up was not significantly different from the score obtained at baseline. However, the participants with diabetes, especially combined with hypertension at baseline, had significantly lower MoCA-J scores than those without lifestyle-related diseases. The combination of hypertension and diabetes was still a significant risk factor for cognitive decline, considering the MoCA-J scores obtained during the follow-up after adjustments at baseline, relative to sex, body mass index, dyslipidemia, smoking, excessive alcohol intake, antihypertensive treatment and education level (β=-0.14; P<0.01). Our findings indicate that diabetes and the combination of hypertension and diabetes are clear risk factors for future cognitive decline in elderly individuals who are 70 years of age.
KW - cognitive functioning
KW - diabetes mellitus
KW - older population
UR - http://www.scopus.com/inward/record.url?scp=85021741018&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85021741018&partnerID=8YFLogxK
U2 - 10.1038/hr.2017.15
DO - 10.1038/hr.2017.15
M3 - Article
C2 - 28230198
AN - SCOPUS:85021741018
SN - 0916-9636
VL - 40
SP - 665
EP - 670
JO - Hypertension Research
JF - Hypertension Research
IS - 7
ER -
