Longitudinal long COVID symptoms in Japanese patients after COVID-19 vaccinations

Kensuke Nakagawara; Atsuho Morita; Ho Namkoong; Hideki Terai; Shotaro Chubachi; Takanori Asakura; Hiromu Tanaka; Fumimaro Ito; Emiko Matsuyama; Masanori Kaji; Ayaka Saito; Hatsuyo Takaoka; Masahiko Okada; Keeya Sunata; Mayuko Watase; Kazuma Yagi; Keiko Ohgino; Jun Miyata; Hirofumi Kamata; Ichiro Kawada; Keigo Kobayashi; Toshiyuki Hirano; Takashi Inoue; Junko Kagyo; Tetsuya Shiomi; Kengo Otsuka; Naoki Miyao; Toshio Odani; Rie Baba; Daisuke Arai; Ichiro Nakachi; Soichiro Ueda; Yohei Funatsu; Hidefumi Koh; Kota Ishioka; Saeko Takahashi; Morio Nakamura; Toshiro Sato; Naoki Hasegawa; Yuko Kitagawa; Takanori Kanai; Makoto Ishii; Koichi Fukunaga

doi:10.1016/j.jvacx.2023.100381

Longitudinal long COVID symptoms in Japanese patients after COVID-19 vaccinations

Kensuke Nakagawara, Atsuho Morita, Ho Namkoong, Hideki Terai, Shotaro Chubachi, Takanori Asakura, Hiromu Tanaka, Fumimaro Ito, Emiko Matsuyama, Masanori Kaji, Ayaka Saito, Hatsuyo Takaoka, Masahiko Okada, Keeya Sunata, Mayuko Watase, Kazuma Yagi, Keiko Ohgino, Jun Miyata, Hirofumi Kamata, Ichiro KawadaKeigo Kobayashi, Toshiyuki Hirano, Takashi Inoue, Junko Kagyo, Tetsuya Shiomi, Kengo Otsuka, Naoki Miyao, Toshio Odani, Rie Baba, Daisuke Arai, Ichiro Nakachi, Soichiro Ueda, Yohei Funatsu, Hidefumi Koh, Kota Ishioka, Saeko Takahashi, Morio Nakamura, Toshiro Sato, Naoki Hasegawa, Yuko Kitagawa, Takanori Kanai, Makoto Ishii, Koichi Fukunaga

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

We conducted a subgroup analysis of a study on the long-term effects of COVID-19 (long COVID) in Japan to assess the effect of vaccination on long COVID symptoms. We assessed the clinical course of 111 patients with long COVID at the time of vaccination. The follow-up period was one year from the onset of COVID-19 or until the administration of the third vaccine dose. Of the 111 patients, 15 (13.5%) reported improvement, four (3.6%) reported deterioration, and 92 (82.9%) reported no change in their long COVID symptoms after vaccination. The most common long COVID symptoms before vaccination were alopecia, dyspnea, muscle weakness, fatigue, and headache among participants whose symptoms improved. Reduced dyspnea and alopecia were the most frequently reported improvements in symptoms after vaccination. Some symptoms persisted, including sleep disturbance, myalgia, and hypersensitivity. Vaccination did not appear to have a clinically important effect on patients with long COVID symptoms.

Original language	English
Article number	100381
Journal	Vaccine: X
Volume	15
DOIs	https://doi.org/10.1016/j.jvacx.2023.100381
Publication status	Published - 2023 Dec

Keywords

SARS-CoV-2 infection
Vaccination
post-COVID-19 syndrome

ASJC Scopus subject areas

Molecular Medicine
General Immunology and Microbiology
General Veterinary
Public Health, Environmental and Occupational Health
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jvacx.2023.100381

Cite this

Nakagawara, K., Morita, A., Namkoong, H., Terai, H., Chubachi, S., Asakura, T., Tanaka, H., Ito, F., Matsuyama, E., Kaji, M., Saito, A., Takaoka, H., Okada, M., Sunata, K., Watase, M., Yagi, K., Ohgino, K., Miyata, J., Kamata, H., ... Fukunaga, K. (2023). Longitudinal long COVID symptoms in Japanese patients after COVID-19 vaccinations. Vaccine: X, 15, Article 100381. https://doi.org/10.1016/j.jvacx.2023.100381

Nakagawara, K, Morita, A, Namkoong, H, Terai, H , Chubachi, S, Asakura, T, Tanaka, H, Ito, F, Matsuyama, E, Kaji, M, Saito, A, Takaoka, H, Okada, M, Sunata, K, Watase, M, Yagi, K, Ohgino, K , Miyata, J, Kamata, H, Kawada, I, Kobayashi, K, Hirano, T, Inoue, T, Kagyo, J, Shiomi, T, Otsuka, K, Miyao, N, Odani, T, Baba, R, Arai, D, Nakachi, I, Ueda, S, Funatsu, Y, Koh, H, Ishioka, K, Takahashi, S, Nakamura, M, Sato, T , Hasegawa, N , Kitagawa, Y , Kanai, T, Ishii, M & Fukunaga, K 2023, 'Longitudinal long COVID symptoms in Japanese patients after COVID-19 vaccinations', Vaccine: X, vol. 15, 100381. https://doi.org/10.1016/j.jvacx.2023.100381

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title = "Longitudinal long COVID symptoms in Japanese patients after COVID-19 vaccinations",

abstract = "We conducted a subgroup analysis of a study on the long-term effects of COVID-19 (long COVID) in Japan to assess the effect of vaccination on long COVID symptoms. We assessed the clinical course of 111 patients with long COVID at the time of vaccination. The follow-up period was one year from the onset of COVID-19 or until the administration of the third vaccine dose. Of the 111 patients, 15 (13.5%) reported improvement, four (3.6%) reported deterioration, and 92 (82.9%) reported no change in their long COVID symptoms after vaccination. The most common long COVID symptoms before vaccination were alopecia, dyspnea, muscle weakness, fatigue, and headache among participants whose symptoms improved. Reduced dyspnea and alopecia were the most frequently reported improvements in symptoms after vaccination. Some symptoms persisted, including sleep disturbance, myalgia, and hypersensitivity. Vaccination did not appear to have a clinically important effect on patients with long COVID symptoms.",

keywords = "SARS-CoV-2 infection, Vaccination, post-COVID-19 syndrome",

author = "Kensuke Nakagawara and Atsuho Morita and Ho Namkoong and Hideki Terai and Shotaro Chubachi and Takanori Asakura and Hiromu Tanaka and Fumimaro Ito and Emiko Matsuyama and Masanori Kaji and Ayaka Saito and Hatsuyo Takaoka and Masahiko Okada and Keeya Sunata and Mayuko Watase and Kazuma Yagi and Keiko Ohgino and Jun Miyata and Hirofumi Kamata and Ichiro Kawada and Keigo Kobayashi and Toshiyuki Hirano and Takashi Inoue and Junko Kagyo and Tetsuya Shiomi and Kengo Otsuka and Naoki Miyao and Toshio Odani and Rie Baba and Daisuke Arai and Ichiro Nakachi and Soichiro Ueda and Yohei Funatsu and Hidefumi Koh and Kota Ishioka and Saeko Takahashi and Morio Nakamura and Toshiro Sato and Naoki Hasegawa and Yuko Kitagawa and Takanori Kanai and Makoto Ishii and Koichi Fukunaga",

note = "Publisher Copyright: {\textcopyright} 2023 The Author(s)",

year = "2023",

month = dec,

doi = "10.1016/j.jvacx.2023.100381",

language = "English",

volume = "15",

journal = "Vaccine: X",

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T1 - Longitudinal long COVID symptoms in Japanese patients after COVID-19 vaccinations

AU - Nakagawara, Kensuke

AU - Morita, Atsuho

AU - Namkoong, Ho

AU - Terai, Hideki

AU - Chubachi, Shotaro

AU - Asakura, Takanori

AU - Tanaka, Hiromu

AU - Ito, Fumimaro

AU - Matsuyama, Emiko

AU - Kaji, Masanori

AU - Saito, Ayaka

AU - Takaoka, Hatsuyo

AU - Okada, Masahiko

AU - Sunata, Keeya

AU - Watase, Mayuko

AU - Yagi, Kazuma

AU - Ohgino, Keiko

AU - Miyata, Jun

AU - Kamata, Hirofumi

AU - Kawada, Ichiro

AU - Kobayashi, Keigo

AU - Hirano, Toshiyuki

AU - Inoue, Takashi

AU - Kagyo, Junko

AU - Shiomi, Tetsuya

AU - Otsuka, Kengo

AU - Miyao, Naoki

AU - Odani, Toshio

AU - Baba, Rie

AU - Arai, Daisuke

AU - Nakachi, Ichiro

AU - Ueda, Soichiro

AU - Funatsu, Yohei

AU - Koh, Hidefumi

AU - Ishioka, Kota

AU - Takahashi, Saeko

AU - Nakamura, Morio

AU - Sato, Toshiro

AU - Hasegawa, Naoki

AU - Kitagawa, Yuko

AU - Kanai, Takanori

AU - Ishii, Makoto

AU - Fukunaga, Koichi

PY - 2023/12

Y1 - 2023/12

N2 - We conducted a subgroup analysis of a study on the long-term effects of COVID-19 (long COVID) in Japan to assess the effect of vaccination on long COVID symptoms. We assessed the clinical course of 111 patients with long COVID at the time of vaccination. The follow-up period was one year from the onset of COVID-19 or until the administration of the third vaccine dose. Of the 111 patients, 15 (13.5%) reported improvement, four (3.6%) reported deterioration, and 92 (82.9%) reported no change in their long COVID symptoms after vaccination. The most common long COVID symptoms before vaccination were alopecia, dyspnea, muscle weakness, fatigue, and headache among participants whose symptoms improved. Reduced dyspnea and alopecia were the most frequently reported improvements in symptoms after vaccination. Some symptoms persisted, including sleep disturbance, myalgia, and hypersensitivity. Vaccination did not appear to have a clinically important effect on patients with long COVID symptoms.

AB - We conducted a subgroup analysis of a study on the long-term effects of COVID-19 (long COVID) in Japan to assess the effect of vaccination on long COVID symptoms. We assessed the clinical course of 111 patients with long COVID at the time of vaccination. The follow-up period was one year from the onset of COVID-19 or until the administration of the third vaccine dose. Of the 111 patients, 15 (13.5%) reported improvement, four (3.6%) reported deterioration, and 92 (82.9%) reported no change in their long COVID symptoms after vaccination. The most common long COVID symptoms before vaccination were alopecia, dyspnea, muscle weakness, fatigue, and headache among participants whose symptoms improved. Reduced dyspnea and alopecia were the most frequently reported improvements in symptoms after vaccination. Some symptoms persisted, including sleep disturbance, myalgia, and hypersensitivity. Vaccination did not appear to have a clinically important effect on patients with long COVID symptoms.

KW - SARS-CoV-2 infection

KW - Vaccination

KW - post-COVID-19 syndrome

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U2 - 10.1016/j.jvacx.2023.100381

DO - 10.1016/j.jvacx.2023.100381

M3 - Article

AN - SCOPUS:85171373794

SN - 2590-1362

VL - 15

JO - Vaccine: X

JF - Vaccine: X

M1 - 100381

ER -

Longitudinal long COVID symptoms in Japanese patients after COVID-19 vaccinations

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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