Longitudinal monitoring of circulating immune cell phenotypes in anti-neutrophil cytoplasmic antibody-associated vasculitis

Kotaro Matsumoto, Katsuya Suzuki, Hidekata Yasuoka, Junichi Hirahashi, Hiroto Yoshida, Mayu Magi, Mariko Noguchi-Sasaki, Yuko Kaneko, Tsutomu Takeuchi

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

Anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) is a necrotizing multiorgan autoimmune disease that affects small- to medium-sized blood vessels. Despite the improvements in treatments, half of the patients with AAV still experience disease relapses. In this review, we focus on peripheral leukocyte properties and phenotypes in patients with AAV. In particular, we explore longitudinal changes in circulating immune cell phenotypes during the active phase of the disease and treatment. The numbers and phenotypes of leukocytes in peripheral blood were differs between AAV and healthy controls, AAV in active versus inactive phase, AAV in treatment responders versus non-responders, and AAV with and without severe infection. Therefore, biomarkers detected in peripheral blood immune cells may be useful for longitudinal monitoring of disease activity in AAV.

Original languageEnglish
Article number103271
JournalAutoimmunity Reviews
Volume22
Issue number3
DOIs
Publication statusPublished - 2023 Mar

Keywords

  • Anti-neutrophil cytoplasmic antibody-associated vasculitis
  • Gene expression
  • Immuno-phenotyping

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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