The expression of vesicular acetylcholine transporter (VAChT) was examined immunohistochemically in the cholinergic synapses on the spinal motor neuron of the patient with sporadic amyotrophic lateral sclerosis (SALS). VAChT immunoreactive synapses were depleted on surviving motor neurons in SALS, while synaptophysin immunoreactivity was undiminished on the same neurons. This discrepancy suggests that in SALS, loss of cholinergic input on lower motor neurons is an early event, and may be part of the cause of death of those motor neurons.
|Number of pages||5|
|Journal||Journal of Neuropathology and Experimental Neurology|
|Publication status||Published - 1998 Apr|
- Axon collateral
- Inhibitory synapse
- Motor cortex
ASJC Scopus subject areas