Loss of merlin-p85 protein complex in NF2-related tumors

Hideo Takeshima, Toru Nishi, Keizo Yamamoto, Takeshi Kino, Hideo Nakamura, Hideyuki Saya, Masato Kochi, Jun Ichi Kuratsu, Yukitaka Ushio

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


The NF2 tumor suppressor gene product, designated merlin, belongs to the family of molecules that links membranous protein with the cytoskeleton. We have previously shown that merlin was co-immunoprecipitated with a cellular protein, p85, in cultured cell. To analyze the alteration of merlin and associated proteins in surgical specimens, we developed a new method for biotin-labeling of whole cellular proteins. Screening of tumor tissues using our method showed that none of malignant gliomas and half of the NF2-related tumors had altered p85 and merlin. Our detection method seems useful for the screening of merlin alterations in NF2-related tumors.

Original languageEnglish
Pages (from-to)1073-1078
Number of pages6
JournalInternational journal of oncology
Issue number5
Publication statusPublished - 1998 May
Externally publishedYes


  • Biotin
  • Meningioma
  • NF2
  • Vestibular schwannoma
  • p85

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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