Lower cognitive function as a risk factor for anemia among older Japanese women from the longitudinal observation in the SONIC study

Tomoko Noma, Godai Kayo, Mai Kabayama, Yasuyuki Gondo, Saori Yasumoto, Yukie Masui, Ken Sugimoto, Hiroshi Akasaka, Yoichi Takami, Yasushi Takeya, Koichi Yamamoto, Kazunori Ikebe, Yasumichi Arai, Tatsuro Ishizaki, Hiromi Rakugi, Kei Kamide

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Aim: The aging-related increase in the incidence of anemia potentially affects the mortality risk. Lower cognitive function is common among older adults, and anemia is one of the causes of cognitive decline. However, to the best of our knowledge, no study has investigated whether cognitive decline is a risk factor for anemia in older people. Therefore, in this study, we used a 3-year longitudinal evaluation to examine the association of cognitive function with anemia in community-dwelling older adults. Methods: This longitudinal study enrolled participants without anemia (diagnosed based on the World Health Organization's criteria) at baseline. Cognitive function was assessed using the Japanese version of the Montreal Cognitive Assessment. Multiple logistic regression models were used to examine the association between cognitive function at baseline and the presence of anemia 3 years later. Results: Participants were in the 69–71 and 79–81 years age groups, and 974 older people (48.6% men) were enrolled, of whom 126 (12.9%) had anemia after 3 years. After adjusting, cognitive function at baseline was associated with anemia in women, but not in men. Conclusions: Older Japanese women with lower cognitive function have an increased risk for anemia 3 years later. The adoption of a lifestyle that utilizes or improves cognitive function might be important to prevent anemia in older women. Geriatr Gerontol Int 2023; 23: 334–340.

Original languageEnglish
Pages (from-to)334-340
Number of pages7
JournalGeriatrics and Gerontology International
Issue number5
Publication statusPublished - 2023 May


  • anemia
  • cognitive function
  • community-dwelling older people
  • sex-specific

ASJC Scopus subject areas

  • Health(social science)
  • Gerontology
  • Geriatrics and Gerontology


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