Lower striatal dopamine D2/3receptor availability in obsessive-compulsive disorder: A meta-analysis of [11C]-raclopride and [123I]-IBZM studies

Fernando Caravaggio; Natasha Porco; Yusuke Iwata; Shinichiro Nakajima; Philip Gerretsen; Gary Remington; Ariel Graff-Guerrero

doi:10.1016/j.jocrd.2020.100618

Lower striatal dopamine D_2/3receptor availability in obsessive-compulsive disorder: A meta-analysis of [¹¹C]-raclopride and [¹²³I]-IBZM studies

Fernando Caravaggio, Natasha Porco, Yusuke Iwata, Shinichiro Nakajima, Philip Gerretsen, Gary Remington, Ariel Graff-Guerrero

Department of Psychiatry

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

It is unclear whether striatal dopamine D_2/3 receptor (D_2/3R) availability is reduced in obsessive-compulsive disorder (OCD). We conducted a meta-analysis of substituted benzamide radiotracer studies to address this question (k = 4; N = 33 medication-free patients with OCD and N = 38 matched healthy controls). Our meta-analysis suggests that striatal D_2/3R availability is lower in medication-free patients with OCD compared to healthy controls (Cohen's d = 0.97, 95% CI = 0.45–1.50, z = 3.65, I² = 0, p <.0001). Previous studies have not been sufficiently powered to detect this observed effect-size. We recommend that future studies employ larger sample sizes (n ≥ 19 per group), composed of younger OCD patients with greater illness severity, to validate the findings of this meta-analysis. We hope these findings will help guide future dopamine imaging studies in OCD.

Original language	English
Article number	100618
Journal	Journal of Obsessive-Compulsive and Related Disorders
Volume	28
DOIs	https://doi.org/10.1016/j.jocrd.2020.100618
Publication status	Published - 2021 Jan

Keywords

Dopamine
OCD
Obsessive-compulsive disorder
Striatum
meta-Analysis

ASJC Scopus subject areas

Clinical Psychology
Psychiatry and Mental health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.jocrd.2020.100618

Cite this

Caravaggio, F., Porco, N., Iwata, Y., Nakajima, S., Gerretsen, P., Remington, G., & Graff-Guerrero, A. (2021). Lower striatal dopamine D_2/3receptor availability in obsessive-compulsive disorder: A meta-analysis of [¹¹C]-raclopride and [¹²³I]-IBZM studies. Journal of Obsessive-Compulsive and Related Disorders, 28, Article 100618. https://doi.org/10.1016/j.jocrd.2020.100618

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abstract = "It is unclear whether striatal dopamine D2/3 receptor (D2/3R) availability is reduced in obsessive-compulsive disorder (OCD). We conducted a meta-analysis of substituted benzamide radiotracer studies to address this question (k = 4; N = 33 medication-free patients with OCD and N = 38 matched healthy controls). Our meta-analysis suggests that striatal D2/3R availability is lower in medication-free patients with OCD compared to healthy controls (Cohen's d = 0.97, 95% CI = 0.45–1.50, z = 3.65, I2 = 0, p <.0001). Previous studies have not been sufficiently powered to detect this observed effect-size. We recommend that future studies employ larger sample sizes (n ≥ 19 per group), composed of younger OCD patients with greater illness severity, to validate the findings of this meta-analysis. We hope these findings will help guide future dopamine imaging studies in OCD.",

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author = "Fernando Caravaggio and Natasha Porco and Yusuke Iwata and Shinichiro Nakajima and Philip Gerretsen and Gary Remington and Ariel Graff-Guerrero",

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