TY - JOUR
T1 - Lung volume measurement using chest CT in COVID-19 patients
T2 - a cohort study in Japan
AU - Otake, Shiro
AU - Shiraishi, Yusuke
AU - Chubachi, Shotaro
AU - Tanabe, Naoya
AU - Maetani, Tomoki
AU - Asakura, Takanori
AU - Namkoong, Ho
AU - Shimada, Takashi
AU - Azekawa, Shuhei
AU - Nakagawara, Kensuke
AU - Tanaka, Hiromu
AU - Fukushima, Takahiro
AU - Watase, Mayuko
AU - Terai, Hideki
AU - Sasaki, Mamoru
AU - Ueda, Soichiro
AU - Kato, Yukari
AU - Harada, Norihiro
AU - Suzuki, Shoji
AU - Yoshida, Shuichi
AU - Tateno, Hiroki
AU - Yamada, Yoshitake
AU - Jinzaki, Masahiro
AU - Hirai, Toyohiro
AU - Okada, Yukinori
AU - Koike, Ryuji
AU - Ishii, Makoto
AU - Hasegawa, Naoki
AU - Kimura, Akinori
AU - Imoto, Seiya
AU - Miyano, Satoru
AU - Ogawa, Seishi
AU - Kanai, Takanori
AU - Fukunaga, Koichi
N1 - Publisher Copyright:
© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
PY - 2024/4/24
Y1 - 2024/4/24
N2 - Objective This study aimed to investigate the utility of CT quantification of lung volume for predicting critical outcomes in COVID-19 patients. Methods This retrospective cohort study included 1200 hospitalised patients with COVID-19 from 4 hospitals. Lung fields were extracted using artificial intelligence-based segmentation, and the percentage of the predicted (%pred) total lung volume (TLC (%pred)) was calculated. The incidence of critical outcomes and posthospitalisation complications was compared between patients with low and high CT lung volumes classified based on the median percentage of predicted TLCct (n=600 for each). Prognostic factors for residual lung volume loss were investigated in 208 patients with COVID-19 via a follow-up CT after 3 months. Results The incidence of critical outcomes was higher in the low TLCct (%pred) group than in the high TLCct (%pred) group (14.2% vs 3.3%, p<0.0001). Multivariable analysis of previously reported factors (age, sex, body mass index and comorbidities) demonstrated that CT-derived lung volume was significantly associated with critical outcomes. The low TLCct (%pred) group exhibited a higher incidence of bacterial infection, heart failure, thromboembolism, liver dysfunction and renal dysfunction than the high TLCct (%pred) group. TLCct (%pred) at 3 months was similarly divided into two groups at the median (71.8%). Among patients with follow-up CT scans, lung volumes showed a recovery trend from the time of admission to 3 months but remained lower in critical cases at 3 months. Conclusion Lower CT lung volume was associated with critical outcomes, posthospitalisation complications and slower improvement of clinical conditions in COVID-19 patients.
AB - Objective This study aimed to investigate the utility of CT quantification of lung volume for predicting critical outcomes in COVID-19 patients. Methods This retrospective cohort study included 1200 hospitalised patients with COVID-19 from 4 hospitals. Lung fields were extracted using artificial intelligence-based segmentation, and the percentage of the predicted (%pred) total lung volume (TLC (%pred)) was calculated. The incidence of critical outcomes and posthospitalisation complications was compared between patients with low and high CT lung volumes classified based on the median percentage of predicted TLCct (n=600 for each). Prognostic factors for residual lung volume loss were investigated in 208 patients with COVID-19 via a follow-up CT after 3 months. Results The incidence of critical outcomes was higher in the low TLCct (%pred) group than in the high TLCct (%pred) group (14.2% vs 3.3%, p<0.0001). Multivariable analysis of previously reported factors (age, sex, body mass index and comorbidities) demonstrated that CT-derived lung volume was significantly associated with critical outcomes. The low TLCct (%pred) group exhibited a higher incidence of bacterial infection, heart failure, thromboembolism, liver dysfunction and renal dysfunction than the high TLCct (%pred) group. TLCct (%pred) at 3 months was similarly divided into two groups at the median (71.8%). Among patients with follow-up CT scans, lung volumes showed a recovery trend from the time of admission to 3 months but remained lower in critical cases at 3 months. Conclusion Lower CT lung volume was associated with critical outcomes, posthospitalisation complications and slower improvement of clinical conditions in COVID-19 patients.
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U2 - 10.1136/bmjresp-2023-002234
DO - 10.1136/bmjresp-2023-002234
M3 - Article
C2 - 38663888
AN - SCOPUS:85191457797
SN - 2052-4439
VL - 11
JO - BMJ Open Respiratory Research
JF - BMJ Open Respiratory Research
IS - 1
M1 - e002234
ER -