Lynch Syndrome-Associated Gynecological Malignancies

Wataru Yamagami, Daisuke Aoki

Research output: Chapter in Book/Report/Conference proceedingChapter


Lynch syndrome-associated gynecological malignancies include endometrial and ovarian cancer. Endometrial cancer is particularly common following colorectal cancer and may be a sentinel cancer. The lifetime incidence of endometrial cancer in patients with Lynch syndrome is 25–60%. Various studies have examined the characteristics and prognosis of Lynch syndrome-associated gynecological malignancies, but there is no consensus. Endometrial cancer is diagnosed by endometrial biopsy, but there is no established surveillance system. Patient education on initial symptoms, routine endometrial biopsy, and transvaginal ultrasonography are performed in clinical practice, but evidence for the efficacy of these methods is limited. The lifetime incidence of ovarian cancer ranges from 4 to 12% and many patients develop epithelial ovarian cancer. Ovarian cancer is initially diagnosed by imaging, with surgery required for definite pathological diagnosis. There is no surveillance system, but patient education, transvaginal ultrasonography, and measurement of serum CA125 are currently used. Prophylactic hysterectomy and bilateral salpingo-oophorectomy are candidates of surgical procedures for preventing Lynch syndrome-associated gynecological malignancies.

Original languageEnglish
Title of host publicationLynch Syndrome
Subtitle of host publicationMolecular Mechanism and Current Clinical Practice
PublisherSpringer Singapore
Number of pages8
ISBN (Electronic)9789811568916
ISBN (Print)9789811568909
Publication statusPublished - 2020 Jan 1


  • Bilateral salpingo-oophorectomy
  • Endometrial cancer
  • Ovarian cancer
  • Prophylactic hysterectomy

ASJC Scopus subject areas

  • General Medicine


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