TY - JOUR
T1 - Lysophosphatidic acid as a novel cell survival/apoptotic factor
AU - Ye, Xiaoqin
AU - Ishii, Isao
AU - Kingsbury, Marcy A.
AU - Chun, Jerold
N1 - Funding Information:
We thank Dr. N. Fukushima and A. Yang for critical comments on the manuscript. This work was supported by the NIMH, the HFSP, and an unrestricted gift from Merck Research Laboratories.
Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2002/12/30
Y1 - 2002/12/30
N2 - Lysophosphatidic acid (LPA) activates its cognate G protein-coupled receptors (GPCRs) LPA1-3 to exert diverse cellular effects, including cell survival and apoptosis. The potent survival effect of LPA on Schwann cells (SCs) is mediated through the pertussis toxin (PTX)-sensitive Gi/o/phosphoinositide 3-kinase (PI3K)/Akt signaling pathways and possibly enhanced by the activation of PTX-insensitive Rho-dependent pathways. LPA promotes survival of many other cell types mainly through PTX-sensitive Gi/o proteins. Paradoxically, LPA also induces apoptosis in certain cells, such as myeloid progenitor cells, hippocampal neurons, and PC12 cells, in which the activation of the Rho-dependent pathways and caspase cascades has been implicated. The effects of LPA on both cell survival and apoptosis underscore important roles for this lipid in normal development and pathological processes.
AB - Lysophosphatidic acid (LPA) activates its cognate G protein-coupled receptors (GPCRs) LPA1-3 to exert diverse cellular effects, including cell survival and apoptosis. The potent survival effect of LPA on Schwann cells (SCs) is mediated through the pertussis toxin (PTX)-sensitive Gi/o/phosphoinositide 3-kinase (PI3K)/Akt signaling pathways and possibly enhanced by the activation of PTX-insensitive Rho-dependent pathways. LPA promotes survival of many other cell types mainly through PTX-sensitive Gi/o proteins. Paradoxically, LPA also induces apoptosis in certain cells, such as myeloid progenitor cells, hippocampal neurons, and PC12 cells, in which the activation of the Rho-dependent pathways and caspase cascades has been implicated. The effects of LPA on both cell survival and apoptosis underscore important roles for this lipid in normal development and pathological processes.
KW - Apoptosis
KW - LPA
KW - LPA receptor
KW - Schwann cell
KW - Survival
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U2 - 10.1016/S1388-1981(02)00330-X
DO - 10.1016/S1388-1981(02)00330-X
M3 - Review article
C2 - 12531543
AN - SCOPUS:0037203315
SN - 1388-1981
VL - 1585
SP - 108
EP - 113
JO - Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
JF - Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
IS - 2-3
ER -