Maintenance of Intestinal Epithelial Homeostasis by Zinc Transporters

Wakana Ohashi, Takafumi Hara, Teruhisa Takagishi, Koji Hase, Toshiyuki Fukada

Research output: Contribution to journalReview articlepeer-review

19 Citations (Scopus)


Zinc is an essential micronutrient for normal organ function, and dysregulation of zinc metabolism has been implicated in a wide range of diseases. Emerging evidence has revealed that zinc transporters play diverse roles in cellular homeostasis and function by regulating zinc trafficking via organelles or the plasma membrane. In the gastrointestinal tract, zinc deficiency leads to diarrhea and dysfunction of intestinal epithelial cells. Studies also showed that zinc transporters are very important in intestinal epithelial homeostasis. In this review, we describe the physiological roles of zinc transporters in intestinal epithelial functions and relevance of zinc transporters in gastrointestinal diseases.

Original languageEnglish
Pages (from-to)2404-2415
Number of pages12
JournalDigestive Diseases and Sciences
Issue number9
Publication statusPublished - 2019 Sept 15


  • Cancer
  • Inflammatory bowel disease
  • Intestinal epithelial cells
  • Zinc
  • Zinc transporter

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology


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