Malignant lymphoma of the cranial vault: Analysis of three cases

The clinicopathological features of three cases with a cranial vault tumor as the initial manifestation of malignant lymphoma are described. Two of them (involving a 47-year-old female and a 53-year-old female) were primary cranial vault lymphoma. Another case (a 50-year-old male) was revealed to have multiple tumors in the cranial vault, right iliac bone and spleen at the first admission examination. All of the cranial vault tumors, which were painless and rapidly growing, invaded the muscle and dura mater from the skull, but not the subdural space or the outside of the superficial fascia. Histological diagnosis of the three cranial vault tumors was non-Hodgkin diffuse large lymphoma. Moreover, the expression pattern of the lymphocytic cell markers, which were examined by immunohistochemistry, was identical; LCA(+), CD20/cy(+), CD79a(+), CD45RO(-), VS38c(-) and CD30(-) indicated that the tumors were B-cell origin without plasmacytic differentiation.