TY - JOUR
T1 - Many ways to generate microRNA-like small RNAs
T2 - Non-canonical pathways for microRNA production
AU - Miyoshi, Keita
AU - Miyoshi, Tomohiro
AU - Siomi, Haruhiko
N1 - Funding Information:
Acknowledgments The authors would like to thank the members of the Siomi Laboratory for discussions. This work was supported by MEXT grants to H.S and K.M, and a Keio University Grant-in-Aid for Encouragement of Young Medical Scientists to K.M.
PY - 2010/8
Y1 - 2010/8
N2 - MicroRNAs (miRNAs) are an abundant class of small non-coding RNAs that collectively regulate the expression of a large number of mRNAs by either promoting destabilization or repressing translation, or both. Therefore, they play a major role in shaping the transcriptomes and proteomes of eukaryotic organisms. Typically, animal miRNAs are produced from long primary transcripts with one or more of hairpin structures by two sequential processing reactions: one by Drosha in the nucleus and the other by Dicer in the cytoplasm. However, deviations from this paradigm have been observed: subclasses of miRNAs, which only partially meet the classical definition of a miRNA, are derived by alternative biogenesis pathways, thereby providing an additional level of complexity to miRNA-dependent regulation of gene expression.
AB - MicroRNAs (miRNAs) are an abundant class of small non-coding RNAs that collectively regulate the expression of a large number of mRNAs by either promoting destabilization or repressing translation, or both. Therefore, they play a major role in shaping the transcriptomes and proteomes of eukaryotic organisms. Typically, animal miRNAs are produced from long primary transcripts with one or more of hairpin structures by two sequential processing reactions: one by Drosha in the nucleus and the other by Dicer in the cytoplasm. However, deviations from this paradigm have been observed: subclasses of miRNAs, which only partially meet the classical definition of a miRNA, are derived by alternative biogenesis pathways, thereby providing an additional level of complexity to miRNA-dependent regulation of gene expression.
KW - Argonaute
KW - Dicer
KW - Drosha
KW - MiRNA
KW - SnoRNA
KW - TRNA
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U2 - 10.1007/s00438-010-0556-1
DO - 10.1007/s00438-010-0556-1
M3 - Review article
C2 - 20596726
AN - SCOPUS:77955290050
SN - 1617-4615
VL - 284
SP - 95
EP - 103
JO - Molecular Genetics and Genomics
JF - Molecular Genetics and Genomics
IS - 2
ER -