Marked reduction in the minimum inhibitory concentration (MIC) of β- lactams in methicillin-resistant Staphylococcus aureus produced by epicatechin gallate, an ingredient of green tea (Camellia sinensis)

Sumiko Shiota; Masato Shimizu; Tohru Mizushima; Hideyuki Ito; Tsutomu Hatano; Takashi Yoshida; Tomofusa Tsuchiya

doi:10.1248/bpb.22.1388

Marked reduction in the minimum inhibitory concentration (MIC) of β- lactams in methicillin-resistant Staphylococcus aureus produced by epicatechin gallate, an ingredient of green tea (Camellia sinensis)

Sumiko Shiota, Masato Shimizu, Tohru Mizushima, Hideyuki Ito, Tsutomu Hatano, Takashi Yoshida, Tomofusa Tsuchiya

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

114 Citations (Scopus)

Abstract

We found that epicatechin gallate, a constituent of an extract of tea leaves (green tea) markedly lowered the minimum inhibitory concentration (MIC) of oxacillin and other β-lactams, but not of other antibacterial agents tested, in strains of methicillin-resistant Staphylococcus aureus. The antibacterial action of epicatechin gallate plus oxacillin was a bactericidal one.

Original language	English
Pages (from-to)	1388-1390
Number of pages	3
Journal	Biological and Pharmaceutical Bulletin
Volume	22
Issue number	12
DOIs	https://doi.org/10.1248/bpb.22.1388
Publication status	Published - 1999 Dec

Keywords

Epicatechin gallate
Methicillin-resistant Staphylococcus aureus (MRSA)
Minimum inhibitory concentration (MIC) reduction
β-lactam

ASJC Scopus subject areas

Pharmacology
Pharmaceutical Science

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Shiota, S., Shimizu, M., Mizushima, T., Ito, H., Hatano, T., Yoshida, T., & Tsuchiya, T. (1999). Marked reduction in the minimum inhibitory concentration (MIC) of β- lactams in methicillin-resistant Staphylococcus aureus produced by epicatechin gallate, an ingredient of green tea (Camellia sinensis). Biological and Pharmaceutical Bulletin, 22(12), 1388-1390. https://doi.org/10.1248/bpb.22.1388

Marked reduction in the minimum inhibitory concentration (MIC) of β- lactams in methicillin-resistant Staphylococcus aureus produced by epicatechin gallate, an ingredient of green tea (Camellia sinensis). / Shiota, Sumiko; Shimizu, Masato; Mizushima, Tohru et al.
In: Biological and Pharmaceutical Bulletin, Vol. 22, No. 12, 12.1999, p. 1388-1390.

Research output: Contribution to journal › Article › peer-review

Shiota, S, Shimizu, M, Mizushima, T, Ito, H, Hatano, T, Yoshida, T & Tsuchiya, T 1999, 'Marked reduction in the minimum inhibitory concentration (MIC) of β- lactams in methicillin-resistant Staphylococcus aureus produced by epicatechin gallate, an ingredient of green tea (Camellia sinensis)', Biological and Pharmaceutical Bulletin, vol. 22, no. 12, pp. 1388-1390. https://doi.org/10.1248/bpb.22.1388

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Marked reduction in the minimum inhibitory concentration (MIC) of β- lactams in methicillin-resistant Staphylococcus aureus produced by epicatechin gallate, an ingredient of green tea (Camellia sinensis)

Abstract

Keywords

ASJC Scopus subject areas

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