Mechanical property of in vitro regenerated cartilage

Shogo Miyata; Takashi Ushida; Guoping Chen; Yasuo Nitta; Tetsuya Tateishi

doi:10.1299/kikaia.69.90

Mechanical property of in vitro regenerated cartilage

Shogo Miyata, Takashi Ushida, Guoping Chen, Yasuo Nitta, Tetsuya Tateishi

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Damaged articular cartilage has a very limited capability of self-healing. The need for improved treatment of cartilage defects, which involve over 1 percent of population in Japan, has motivated research to create regenerated cartilage. Regenerated cartilage is engineered by culturing autologous chondrocytes on biodegradable scaffolds. We studied changes in biomechanical property, especially dynamic visco-elasticity during 6 weeks of in vitro culture. The results suggest that the ability of water holding was increased by new extracellular matrix (ECM) synthesis during 4 weeks of in vitro culture, although the ability of solid matrix (ECM and scaffold) to resist compression elastically was reduced.

Original language	English
Pages (from-to)	90-94
Number of pages	5
Journal	Nippon Kikai Gakkai Ronbunshu, A Hen/Transactions of the Japan Society of Mechanical Engineers, Part A
Volume	69
Issue number	1
DOIs	https://doi.org/10.1299/kikaia.69.90
Publication status	Published - 2003 Jan
Externally published	Yes

Keywords

Biomaterials
Mechanical property
Medical engineering
Regenerated cartilage
Visco elasticity

ASJC Scopus subject areas

Materials Science(all)
Mechanics of Materials
Mechanical Engineering

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AU - Miyata, Shogo

AU - Ushida, Takashi

AU - Chen, Guoping

AU - Nitta, Yasuo

AU - Tateishi, Tetsuya

PY - 2003/1

Y1 - 2003/1

N2 - Damaged articular cartilage has a very limited capability of self-healing. The need for improved treatment of cartilage defects, which involve over 1 percent of population in Japan, has motivated research to create regenerated cartilage. Regenerated cartilage is engineered by culturing autologous chondrocytes on biodegradable scaffolds. We studied changes in biomechanical property, especially dynamic visco-elasticity during 6 weeks of in vitro culture. The results suggest that the ability of water holding was increased by new extracellular matrix (ECM) synthesis during 4 weeks of in vitro culture, although the ability of solid matrix (ECM and scaffold) to resist compression elastically was reduced.

AB - Damaged articular cartilage has a very limited capability of self-healing. The need for improved treatment of cartilage defects, which involve over 1 percent of population in Japan, has motivated research to create regenerated cartilage. Regenerated cartilage is engineered by culturing autologous chondrocytes on biodegradable scaffolds. We studied changes in biomechanical property, especially dynamic visco-elasticity during 6 weeks of in vitro culture. The results suggest that the ability of water holding was increased by new extracellular matrix (ECM) synthesis during 4 weeks of in vitro culture, although the ability of solid matrix (ECM and scaffold) to resist compression elastically was reduced.

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KW - Mechanical property

KW - Medical engineering

KW - Regenerated cartilage

KW - Visco elasticity

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Mechanical property of in vitro regenerated cartilage

Abstract

Keywords

ASJC Scopus subject areas

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