Mechanisms of the cerebral cortical development

Kazuma Kobayashi, Kazunori Nakajima

Research output: Contribution to journalReview articlepeer-review


The development of cerebral cortex is regulated by complex mechanisms. Various classes of neurons migrate from the proliferative zones to the cortex according to a spatiotemporal manner. There are two distinct modes of neuronal migration: radial migration and tangential migration. In the benefit of the advancement of research techniques such as in utero electroporation and time-lapse observation of living tissues, more aspects of the cell and molecular mechanisms that control these two migration modes and their roles in the cortical development have been clarified.

Original languageEnglish
Pages (from-to)395-403
Number of pages9
JournalBrain and Nerve
Issue number4
Publication statusPublished - 2008 Apr


  • Cerebral cortex
  • Neuronal migration
  • Radial migration
  • Reelin
  • Tangential migration

ASJC Scopus subject areas

  • General Neuroscience


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