The EtOH extract of tarragon Artemisia dracunculus, a perennial herb in the family Asteraceae, was found to potently inhibit α-melanocyte-stimulating hormone (α-MSH) induced melanin production in B16 mouse melanoma cells. Bioassay-guided fractionation led to the isolation of two alkamide compounds, isobutyl (1) and piperidiyl (2) amides of undeca-2E,4E-dien-8,10- dynoic acid. The respective EC 50 values for melanin biosynthesis inhibition were 1.8 and 2.3μg/mL for 1 and 2.
- Melanin biosynthesis inhibitor
- α-melanocyte- stimulating hormone (α-MSH)
ASJC Scopus subject areas
- Analytical Chemistry
- Applied Microbiology and Biotechnology
- Molecular Biology
- Organic Chemistry