Melanin biosynthesis inhibitors from tarragon Artemisia dracunculus

Masayoshi Yamada; Kazuhiko Nakamura; Taeko Watabe; Osamu Ohno; Masaru Kawagoshi; Norihito Maru; Nobuo Uotsu; Tomohiro Chiba; Kohji Yamaguchi; Daisuke Uemura

doi:10.1271/bbb.110306

Melanin biosynthesis inhibitors from tarragon Artemisia dracunculus

Masayoshi Yamada, Kazuhiko Nakamura, Taeko Watabe, Osamu Ohno, Masaru Kawagoshi, Norihito Maru, Nobuo Uotsu, Tomohiro Chiba, Kohji Yamaguchi, Daisuke Uemura

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

The EtOH extract of tarragon Artemisia dracunculus, a perennial herb in the family Asteraceae, was found to potently inhibit α-melanocyte-stimulating hormone (α-MSH) induced melanin production in B16 mouse melanoma cells. Bioassay-guided fractionation led to the isolation of two alkamide compounds, isobutyl (1) and piperidiyl (2) amides of undeca-2E,4E-dien-8,10- dynoic acid. The respective EC ₅₀ values for melanin biosynthesis inhibition were 1.8 and 2.3μg/mL for 1 and 2.

Original language	English
Pages (from-to)	1628-1630
Number of pages	3
Journal	Bioscience, Biotechnology and Biochemistry
Volume	75
Issue number	8
DOIs	https://doi.org/10.1271/bbb.110306
Publication status	Published - 2011
Externally published	Yes

Keywords

Alkamide
Melanin biosynthesis inhibitor
Skin-whitening
α-melanocyte- stimulating hormone (α-MSH)

ASJC Scopus subject areas

Biotechnology
Analytical Chemistry
Biochemistry
Applied Microbiology and Biotechnology
Molecular Biology
Organic Chemistry

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10.1271/bbb.110306

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@article{2480ba2f78cc4620b2e9d648ea57abe6,

title = "Melanin biosynthesis inhibitors from tarragon Artemisia dracunculus",

abstract = "The EtOH extract of tarragon Artemisia dracunculus, a perennial herb in the family Asteraceae, was found to potently inhibit α-melanocyte-stimulating hormone (α-MSH) induced melanin production in B16 mouse melanoma cells. Bioassay-guided fractionation led to the isolation of two alkamide compounds, isobutyl (1) and piperidiyl (2) amides of undeca-2E,4E-dien-8,10- dynoic acid. The respective EC 50 values for melanin biosynthesis inhibition were 1.8 and 2.3μg/mL for 1 and 2.",

keywords = "Alkamide, Melanin biosynthesis inhibitor, Skin-whitening, α-melanocyte- stimulating hormone (α-MSH)",

author = "Masayoshi Yamada and Kazuhiko Nakamura and Taeko Watabe and Osamu Ohno and Masaru Kawagoshi and Norihito Maru and Nobuo Uotsu and Tomohiro Chiba and Kohji Yamaguchi and Daisuke Uemura",

note = "Funding Information: This work was supported in part by JSPS via grant-aid for scientific research (21221009 and 22603008).",

year = "2011",

doi = "10.1271/bbb.110306",

language = "English",

volume = "75",

pages = "1628--1630",

journal = "Bioscience, Biotechnology and Biochemistry",

issn = "0916-8451",

publisher = "Japan Society for Bioscience Biotechnology and Agrochemistry",

number = "8",

}

TY - JOUR

T1 - Melanin biosynthesis inhibitors from tarragon Artemisia dracunculus

AU - Yamada, Masayoshi

AU - Nakamura, Kazuhiko

AU - Watabe, Taeko

AU - Ohno, Osamu

AU - Kawagoshi, Masaru

AU - Maru, Norihito

AU - Uotsu, Nobuo

AU - Chiba, Tomohiro

AU - Yamaguchi, Kohji

AU - Uemura, Daisuke

N1 - Funding Information: This work was supported in part by JSPS via grant-aid for scientific research (21221009 and 22603008).

PY - 2011

Y1 - 2011

N2 - The EtOH extract of tarragon Artemisia dracunculus, a perennial herb in the family Asteraceae, was found to potently inhibit α-melanocyte-stimulating hormone (α-MSH) induced melanin production in B16 mouse melanoma cells. Bioassay-guided fractionation led to the isolation of two alkamide compounds, isobutyl (1) and piperidiyl (2) amides of undeca-2E,4E-dien-8,10- dynoic acid. The respective EC 50 values for melanin biosynthesis inhibition were 1.8 and 2.3μg/mL for 1 and 2.

AB - The EtOH extract of tarragon Artemisia dracunculus, a perennial herb in the family Asteraceae, was found to potently inhibit α-melanocyte-stimulating hormone (α-MSH) induced melanin production in B16 mouse melanoma cells. Bioassay-guided fractionation led to the isolation of two alkamide compounds, isobutyl (1) and piperidiyl (2) amides of undeca-2E,4E-dien-8,10- dynoic acid. The respective EC 50 values for melanin biosynthesis inhibition were 1.8 and 2.3μg/mL for 1 and 2.

KW - Alkamide

KW - Melanin biosynthesis inhibitor

KW - Skin-whitening

KW - α-melanocyte- stimulating hormone (α-MSH)

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U2 - 10.1271/bbb.110306

DO - 10.1271/bbb.110306

M3 - Article

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AN - SCOPUS:80051974225

SN - 0916-8451

VL - 75

SP - 1628

EP - 1630

JO - Bioscience, Biotechnology and Biochemistry

JF - Bioscience, Biotechnology and Biochemistry

IS - 8

ER -

Melanin biosynthesis inhibitors from tarragon Artemisia dracunculus

Abstract

Keywords

ASJC Scopus subject areas

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