TY - JOUR
T1 - Mesenchymal stem cell-based tissue regeneration therapies for periodontitis
AU - Ouchi, Takehito
AU - Nakagawa, Taneaki
N1 - Funding Information:
This work was supported by the Japan Society for the Promotion of Science KAKENHI , grant numbers 18K17034 (TO). We would like to thank Editage ( www.editage.jp ) for English language editing. The authors are grateful to KAAK studio (Keisuke Koyama: Dentist and Oral Surgeon) for preparing the illustrations.
Publisher Copyright:
© 2020 The Japanese Society for Regenerative Medicine
PY - 2020/6
Y1 - 2020/6
N2 - Periodontitis is commonly observed and is an important concern in dental health. It is characterized by a multifactorial etiology, including imbalance of oral microbiota, mechanical stress, and systemic diseases such as diabetes mellitus. The current standard treatments for periodontitis include elimination of the microbial pathogen and application of biomaterials for treating bone defects. However, the periodontal tissue regeneration via a process consistent with the natural tissue formation process has not yet been achieved. Developmental biology studies state that periodontal tissue is composed of neural crest-derived ectomesenchyme. To elucidate the process of periodontal regeneration, it is essential to understand the developmental background and intercellular cross-talk. Several recent studies have reported the efficacy of transplantation of mesenchymal stem cells for periodontal tissue regeneration. In this review, we discuss the basic knowledge of periodontal tissue regeneration using mesenchymal stem cells and highlight the potential of stem cell-based periodontal regenerative medicine.
AB - Periodontitis is commonly observed and is an important concern in dental health. It is characterized by a multifactorial etiology, including imbalance of oral microbiota, mechanical stress, and systemic diseases such as diabetes mellitus. The current standard treatments for periodontitis include elimination of the microbial pathogen and application of biomaterials for treating bone defects. However, the periodontal tissue regeneration via a process consistent with the natural tissue formation process has not yet been achieved. Developmental biology studies state that periodontal tissue is composed of neural crest-derived ectomesenchyme. To elucidate the process of periodontal regeneration, it is essential to understand the developmental background and intercellular cross-talk. Several recent studies have reported the efficacy of transplantation of mesenchymal stem cells for periodontal tissue regeneration. In this review, we discuss the basic knowledge of periodontal tissue regeneration using mesenchymal stem cells and highlight the potential of stem cell-based periodontal regenerative medicine.
KW - Mesenchymal stem cells
KW - Periodontal tissue
KW - Periodontitis
KW - Pluripotent stem cells
KW - Tissue regeneration
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U2 - 10.1016/j.reth.2019.12.011
DO - 10.1016/j.reth.2019.12.011
M3 - Review article
AN - SCOPUS:85077750310
SN - 2352-3204
VL - 14
SP - 72
EP - 78
JO - Regenerative Therapy
JF - Regenerative Therapy
ER -
