TY - JOUR
T1 - Meta-Analysis
T2 - Effects of probiotic supplementation on lipid profiles in normal to mildly hypercholesterolemic individuals
AU - Shimizu, Mikiko
AU - Hashiguchi, Masayuki
AU - Shiga, Tsuyoshi
AU - Tamura, Hiro Omi
AU - Mochizuki, Mayumi
N1 - Funding Information:
This work was supported by Japan Society for the Promotion of Science Kakenhi Grant No. 90396391; a Grant-in-Aid for Scientific Research (C) in Japan; Grants for Encouragement of Research, Japan Research Foundation for Clinical Pharmacology; and by the Nagai Foundation, Tokyo, in Japan. All authors declare no conflict of interest.
Publisher Copyright:
© 2015 Shimizu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2015/10/16
Y1 - 2015/10/16
N2 - Introduction Recent experimental and clinical studies have suggested that probiotic supplementation has beneficial effects on serum lipid profiles. However, there are conflicting results on the efficacy of probiotic preparations in reducing serum cholesterol. Objective To evaluate the effects of probiotics on human serum lipid levels, we conducted a metaanalysis of interventional studies. Methods Eligible reports were obtained by searches of electronic databases. We included randomized, controlled clinical trials comparing probiotic supplementation with placebo or no treatment (control). Statistical analysis was performed with Review Manager 5.3.3. Subanalyses were also performed. Results Eleven of 33 randomized clinical trials retrieved were eligible for inclusion in the meta-Analysis. No participant had received any cholesterol-lowering agent. Probiotic interventions (including fermented milk products and probiotics) produced changes in total cholesterol (TC) (mean difference-0.17 mmol/L, 95% CI:-0.27 to-0.07 mmol/L) and low-density lipoprotein cholesterol (LDL-C) (mean difference-0.22 mmol/L, 95% CI:-0.30 to-0.13 mmol/ L). High-density lipoprotein cholesterol and triglyceride levels did not differ significantly between probiotic and control groups. In subanalysis, long-Term (>4-week) probiotic intervention was statistically more effective in decreasing TC and LDL-C than short-Term (4-week) intervention. The decreases in TC and LDL-C levels with probiotic intervention were greater in mildly hypercholesterolemic than in normocholesterolemic individuals. Both fermented milk product and probiotic preparations decreased TC and LDL-C levels. Gaio and the Lactobacillus acidophilus strain reduced TC and LDL-C levels to a greater extent than other bacterial strains. Conclusions In conclusion, this meta-Analysis showed that probiotic supplementation could be useful in the primary prevention of hypercholesterolemia and may lead to reductions in risk factors for cardiovascular disease.
AB - Introduction Recent experimental and clinical studies have suggested that probiotic supplementation has beneficial effects on serum lipid profiles. However, there are conflicting results on the efficacy of probiotic preparations in reducing serum cholesterol. Objective To evaluate the effects of probiotics on human serum lipid levels, we conducted a metaanalysis of interventional studies. Methods Eligible reports were obtained by searches of electronic databases. We included randomized, controlled clinical trials comparing probiotic supplementation with placebo or no treatment (control). Statistical analysis was performed with Review Manager 5.3.3. Subanalyses were also performed. Results Eleven of 33 randomized clinical trials retrieved were eligible for inclusion in the meta-Analysis. No participant had received any cholesterol-lowering agent. Probiotic interventions (including fermented milk products and probiotics) produced changes in total cholesterol (TC) (mean difference-0.17 mmol/L, 95% CI:-0.27 to-0.07 mmol/L) and low-density lipoprotein cholesterol (LDL-C) (mean difference-0.22 mmol/L, 95% CI:-0.30 to-0.13 mmol/ L). High-density lipoprotein cholesterol and triglyceride levels did not differ significantly between probiotic and control groups. In subanalysis, long-Term (>4-week) probiotic intervention was statistically more effective in decreasing TC and LDL-C than short-Term (4-week) intervention. The decreases in TC and LDL-C levels with probiotic intervention were greater in mildly hypercholesterolemic than in normocholesterolemic individuals. Both fermented milk product and probiotic preparations decreased TC and LDL-C levels. Gaio and the Lactobacillus acidophilus strain reduced TC and LDL-C levels to a greater extent than other bacterial strains. Conclusions In conclusion, this meta-Analysis showed that probiotic supplementation could be useful in the primary prevention of hypercholesterolemia and may lead to reductions in risk factors for cardiovascular disease.
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U2 - 10.1371/journal.pone.0139795
DO - 10.1371/journal.pone.0139795
M3 - Article
C2 - 26473340
AN - SCOPUS:84949519623
SN - 1932-6203
VL - 10
JO - PloS one
JF - PloS one
IS - 10
M1 - e0139795
ER -
