Metabolome analysis and metabolic simulation

Nobuyoshi Ishii, Tomoyoshi Soga, Takaaki Nishioka, Masaru Tomita

Research output: Contribution to journalReview articlepeer-review

13 Citations (Scopus)


For many decades microorganisms have been used for industrial purposes; traditional fermentations such as brewing and production of food additives, aroma molecules, organic acids and pharmaceutical-like antibiotics or recombinant proteins are instances of the industrial microorganism utilization. Therefore, microorganism modeling and simulation have been required for engineering purposes, because of demands for design, optimization and quality control of large-scale fermentation plants. Modeling has recently become more highly developed, aided by the deciphering of microorganism genomes, the completion of metabolic databases, the development of analytical methodologies and improvements in the performance of computers. This paper reviews past and recent metabolic simulation of microorganisms, and also discusses the metabolome analytical techniques and the construction of large-scale microorganism models which are now being developed in our group.

Original languageEnglish
Pages (from-to)29-37
Number of pages9
Issue number1
Publication statusPublished - 2005 Mar


  • Capillary electrophoresis
  • Mass spectrometry
  • Metabolome
  • Microorganism
  • Simulation

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Clinical Biochemistry


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