Methotrexate-associated intravascular large B-cell lymphoma in a patient with rheumatoid arthritis

Jun Kikuchi; Yuko Kaneko; Hidenori Kasahara; Katsura Emoto; Akiharu Kubo; Shinichiro Okamoto; Tsutomu Takeuchi

doi:10.2169/internalmedicine.55.6943

Methotrexate-associated intravascular large B-cell lymphoma in a patient with rheumatoid arthritis

Jun Kikuchi, Yuko Kaneko, Hidenori Kasahara, Katsura Emoto, Akiharu Kubo, Shinichiro Okamoto, Tsutomu Takeuchi

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Intravascular large B-cell lymphoma (IVLBCL) is a rare and clinically aggressive lymphoma with an unfavorable prognosis. We report the case of a 50-year-old woman who was diagnosed with IVLBCL during treatment with methotrexate (MTX) and biologic agents for rheumatoid arthritis. The symptoms showed partial improvement only after the cessation of both treatments. She subsequently received chemotherapy and achieved a complete remission and has remained free of recurrence for 2 years without any further treatment. We herein describe a rare case of IVLBCL which presented with the features of an MTX-associated lymphoproliferative disorder.

Original language	English
Pages (from-to)	1661-1665
Number of pages	5
Journal	Internal Medicine
Volume	55
Issue number	12
DOIs	https://doi.org/10.2169/internalmedicine.55.6943
Publication status	Published - 2016

Keywords

Intravascular lymphoma
Methotrexate
Rheumatoid arthritis
Spontaneous regression

ASJC Scopus subject areas

Internal Medicine

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10.2169/internalmedicine.55.6943

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abstract = "Intravascular large B-cell lymphoma (IVLBCL) is a rare and clinically aggressive lymphoma with an unfavorable prognosis. We report the case of a 50-year-old woman who was diagnosed with IVLBCL during treatment with methotrexate (MTX) and biologic agents for rheumatoid arthritis. The symptoms showed partial improvement only after the cessation of both treatments. She subsequently received chemotherapy and achieved a complete remission and has remained free of recurrence for 2 years without any further treatment. We herein describe a rare case of IVLBCL which presented with the features of an MTX-associated lymphoproliferative disorder.",

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AU - Kikuchi, Jun

AU - Kaneko, Yuko

AU - Kasahara, Hidenori

AU - Emoto, Katsura

AU - Kubo, Akiharu

AU - Okamoto, Shinichiro

AU - Takeuchi, Tsutomu

PY - 2016

Y1 - 2016

N2 - Intravascular large B-cell lymphoma (IVLBCL) is a rare and clinically aggressive lymphoma with an unfavorable prognosis. We report the case of a 50-year-old woman who was diagnosed with IVLBCL during treatment with methotrexate (MTX) and biologic agents for rheumatoid arthritis. The symptoms showed partial improvement only after the cessation of both treatments. She subsequently received chemotherapy and achieved a complete remission and has remained free of recurrence for 2 years without any further treatment. We herein describe a rare case of IVLBCL which presented with the features of an MTX-associated lymphoproliferative disorder.

AB - Intravascular large B-cell lymphoma (IVLBCL) is a rare and clinically aggressive lymphoma with an unfavorable prognosis. We report the case of a 50-year-old woman who was diagnosed with IVLBCL during treatment with methotrexate (MTX) and biologic agents for rheumatoid arthritis. The symptoms showed partial improvement only after the cessation of both treatments. She subsequently received chemotherapy and achieved a complete remission and has remained free of recurrence for 2 years without any further treatment. We herein describe a rare case of IVLBCL which presented with the features of an MTX-associated lymphoproliferative disorder.

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KW - Rheumatoid arthritis

KW - Spontaneous regression

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Methotrexate-associated intravascular large B-cell lymphoma in a patient with rheumatoid arthritis

Abstract

Keywords

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