Methotrexate-associated intravascular large B-cell lymphoma in a patient with rheumatoid arthritis

Jun Kikuchi, Yuko Kaneko, Hidenori Kasahara, Katsura Emoto, Akiharu Kubo, Shinichiro Okamoto, Tsutomu Takeuchi

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


Intravascular large B-cell lymphoma (IVLBCL) is a rare and clinically aggressive lymphoma with an unfavorable prognosis. We report the case of a 50-year-old woman who was diagnosed with IVLBCL during treatment with methotrexate (MTX) and biologic agents for rheumatoid arthritis. The symptoms showed partial improvement only after the cessation of both treatments. She subsequently received chemotherapy and achieved a complete remission and has remained free of recurrence for 2 years without any further treatment. We herein describe a rare case of IVLBCL which presented with the features of an MTX-associated lymphoproliferative disorder.

Original languageEnglish
Pages (from-to)1661-1665
Number of pages5
JournalInternal Medicine
Issue number12
Publication statusPublished - 2016


  • Intravascular lymphoma
  • Methotrexate
  • Rheumatoid arthritis
  • Spontaneous regression

ASJC Scopus subject areas

  • Internal Medicine


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