Methotrexate-associated lymphoproliferative disorder of the stomach presumed to be mucosa-associated lymphoid tissue lymphoma

Sho Ishigaki; Tatsuhiro Masaoka; Hisako Kameyama; Miho Kawaida; Kaori Kameyama; Takehiko Mori; Takanori Kanai

doi:10.2169/internalmedicine.0737-18

Methotrexate-associated lymphoproliferative disorder of the stomach presumed to be mucosa-associated lymphoid tissue lymphoma

Sho Ishigaki, Tatsuhiro Masaoka, Hisako Kameyama, Miho Kawaida, Kaori Kameyama, Takehiko Mori, Takanori Kanai

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

The number of patients with methotrexate-associated lymphoproliferative disorder (MTX-LPD) is increasing. We describe a case of MTX-LPD of the stomach. After treatment with methotrexate for rheumatoid arthritis, the patient developed left cervical lymphadenopathy and an ulcerative lesion in the stomach, which was presumed to be a mucosa-associated lymphoid tissue (MALT) lymphoma. However, we suspected MTX-LPD, based on the clinical course and the positivity of in situ hybridization for the detection of the Epstein-Barr encoding region. After the cessation of MTX, the left cervical lymphadenopathy and the gastric lesion disappeared. This is first report of gastric MTX-LPD that was presumed to be MALT lymphoma.

Original language	English
Pages (from-to)	3249-3254
Number of pages	6
Journal	Internal Medicine
Volume	57
Issue number	22
DOIs	https://doi.org/10.2169/internalmedicine.0737-18
Publication status	Published - 2018

Keywords

Lymphoproliferative disorder
MALT lymphoma
Methotrexate
Rheumatoid arthritis

ASJC Scopus subject areas

Internal Medicine

Access to Document

10.2169/internalmedicine.0737-18

Cite this

@article{3c77f63f173e4336aefa9a9022a3d3f0,

title = "Methotrexate-associated lymphoproliferative disorder of the stomach presumed to be mucosa-associated lymphoid tissue lymphoma",

abstract = "The number of patients with methotrexate-associated lymphoproliferative disorder (MTX-LPD) is increasing. We describe a case of MTX-LPD of the stomach. After treatment with methotrexate for rheumatoid arthritis, the patient developed left cervical lymphadenopathy and an ulcerative lesion in the stomach, which was presumed to be a mucosa-associated lymphoid tissue (MALT) lymphoma. However, we suspected MTX-LPD, based on the clinical course and the positivity of in situ hybridization for the detection of the Epstein-Barr encoding region. After the cessation of MTX, the left cervical lymphadenopathy and the gastric lesion disappeared. This is first report of gastric MTX-LPD that was presumed to be MALT lymphoma.",

keywords = "Lymphoproliferative disorder, MALT lymphoma, Methotrexate, Rheumatoid arthritis",

author = "Sho Ishigaki and Tatsuhiro Masaoka and Hisako Kameyama and Miho Kawaida and Kaori Kameyama and Takehiko Mori and Takanori Kanai",

note = "Publisher Copyright: {\textcopyright} 2018 The Japanese Society of Internal Medicine.",

year = "2018",

doi = "10.2169/internalmedicine.0737-18",

language = "English",

volume = "57",

pages = "3249--3254",

journal = "Internal Medicine",

issn = "0918-2918",

publisher = "Japanese Society of Internal Medicine",

number = "22",

}

TY - JOUR

T1 - Methotrexate-associated lymphoproliferative disorder of the stomach presumed to be mucosa-associated lymphoid tissue lymphoma

AU - Ishigaki, Sho

AU - Masaoka, Tatsuhiro

AU - Kameyama, Hisako

AU - Kawaida, Miho

AU - Kameyama, Kaori

AU - Mori, Takehiko

AU - Kanai, Takanori

PY - 2018

Y1 - 2018

N2 - The number of patients with methotrexate-associated lymphoproliferative disorder (MTX-LPD) is increasing. We describe a case of MTX-LPD of the stomach. After treatment with methotrexate for rheumatoid arthritis, the patient developed left cervical lymphadenopathy and an ulcerative lesion in the stomach, which was presumed to be a mucosa-associated lymphoid tissue (MALT) lymphoma. However, we suspected MTX-LPD, based on the clinical course and the positivity of in situ hybridization for the detection of the Epstein-Barr encoding region. After the cessation of MTX, the left cervical lymphadenopathy and the gastric lesion disappeared. This is first report of gastric MTX-LPD that was presumed to be MALT lymphoma.

AB - The number of patients with methotrexate-associated lymphoproliferative disorder (MTX-LPD) is increasing. We describe a case of MTX-LPD of the stomach. After treatment with methotrexate for rheumatoid arthritis, the patient developed left cervical lymphadenopathy and an ulcerative lesion in the stomach, which was presumed to be a mucosa-associated lymphoid tissue (MALT) lymphoma. However, we suspected MTX-LPD, based on the clinical course and the positivity of in situ hybridization for the detection of the Epstein-Barr encoding region. After the cessation of MTX, the left cervical lymphadenopathy and the gastric lesion disappeared. This is first report of gastric MTX-LPD that was presumed to be MALT lymphoma.

KW - Lymphoproliferative disorder

KW - MALT lymphoma

KW - Methotrexate

KW - Rheumatoid arthritis

UR - http://www.scopus.com/inward/record.url?scp=85056653110&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85056653110&partnerID=8YFLogxK

U2 - 10.2169/internalmedicine.0737-18

DO - 10.2169/internalmedicine.0737-18

M3 - Article

C2 - 30429434

AN - SCOPUS:85056653110

SN - 0918-2918

VL - 57

SP - 3249

EP - 3254

JO - Internal Medicine

JF - Internal Medicine

IS - 22

ER -

Methotrexate-associated lymphoproliferative disorder of the stomach presumed to be mucosa-associated lymphoid tissue lymphoma

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this