Micafungin concentrations in the plasma and burn eschar of severely burned patients

Junichi Sasaki; Satoshi Yamanouchi; Daisuke Kudo; Tomoyuki Endo; Ryosuke Nomura; Kiyotsugu Takuma; Shigeki Kushimoto; Yotaro Shinozawa; Satoshi Kishino; Shingo Hori; Naoki Aikawa

doi:10.1128/AAC.05381-11

Micafungin concentrations in the plasma and burn eschar of severely burned patients

Junichi Sasaki, Satoshi Yamanouchi, Daisuke Kudo, Tomoyuki Endo, Ryosuke Nomura, Kiyotsugu Takuma, Shigeki Kushimoto, Yotaro Shinozawa, Satoshi Kishino, Shingo Hori, Naoki Aikawa

Department of Emergency and Critical Care Medicine

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Micafungin concentrations in plasma and burn eschar after daily intravenous infusion (1 h) of micafungin (200 to 300 mg) were investigated for six patients with severe burns. Micafungin treatment was initiated more than 72 h after the burn injuries. The peak and trough levels in the plasma after the initial administration and repeated administrations for more than 4 days were comparable with or slightly lower than the reported values for healthy volunteers. Micafungin concentrations in the plasma and burn eschar were between 3.6 and >1,000 times higher than the reported MIC₉₀s of micafungin against clinically important Candida and Aspergillus species.

Original language	English
Pages (from-to)	1113-1115
Number of pages	3
Journal	Antimicrobial Agents and Chemotherapy
Volume	56
Issue number	2
DOIs	https://doi.org/10.1128/AAC.05381-11
Publication status	Published - 2012 Feb

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1128/AAC.05381-11

Cite this

@article{2688504e9d4b40178b0feb626e6f250a,

title = "Micafungin concentrations in the plasma and burn eschar of severely burned patients",

abstract = "Micafungin concentrations in plasma and burn eschar after daily intravenous infusion (1 h) of micafungin (200 to 300 mg) were investigated for six patients with severe burns. Micafungin treatment was initiated more than 72 h after the burn injuries. The peak and trough levels in the plasma after the initial administration and repeated administrations for more than 4 days were comparable with or slightly lower than the reported values for healthy volunteers. Micafungin concentrations in the plasma and burn eschar were between 3.6 and >1,000 times higher than the reported MIC90s of micafungin against clinically important Candida and Aspergillus species.",

author = "Junichi Sasaki and Satoshi Yamanouchi and Daisuke Kudo and Tomoyuki Endo and Ryosuke Nomura and Kiyotsugu Takuma and Shigeki Kushimoto and Yotaro Shinozawa and Satoshi Kishino and Shingo Hori and Naoki Aikawa",

year = "2012",

month = feb,

doi = "10.1128/AAC.05381-11",

language = "English",

volume = "56",

pages = "1113--1115",

journal = "Antimicrobial Agents and Chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

number = "2",

}

TY - JOUR

T1 - Micafungin concentrations in the plasma and burn eschar of severely burned patients

AU - Sasaki, Junichi

AU - Yamanouchi, Satoshi

AU - Kudo, Daisuke

AU - Endo, Tomoyuki

AU - Nomura, Ryosuke

AU - Takuma, Kiyotsugu

AU - Kushimoto, Shigeki

AU - Shinozawa, Yotaro

AU - Kishino, Satoshi

AU - Hori, Shingo

AU - Aikawa, Naoki

PY - 2012/2

Y1 - 2012/2

N2 - Micafungin concentrations in plasma and burn eschar after daily intravenous infusion (1 h) of micafungin (200 to 300 mg) were investigated for six patients with severe burns. Micafungin treatment was initiated more than 72 h after the burn injuries. The peak and trough levels in the plasma after the initial administration and repeated administrations for more than 4 days were comparable with or slightly lower than the reported values for healthy volunteers. Micafungin concentrations in the plasma and burn eschar were between 3.6 and >1,000 times higher than the reported MIC90s of micafungin against clinically important Candida and Aspergillus species.

AB - Micafungin concentrations in plasma and burn eschar after daily intravenous infusion (1 h) of micafungin (200 to 300 mg) were investigated for six patients with severe burns. Micafungin treatment was initiated more than 72 h after the burn injuries. The peak and trough levels in the plasma after the initial administration and repeated administrations for more than 4 days were comparable with or slightly lower than the reported values for healthy volunteers. Micafungin concentrations in the plasma and burn eschar were between 3.6 and >1,000 times higher than the reported MIC90s of micafungin against clinically important Candida and Aspergillus species.

UR - http://www.scopus.com/inward/record.url?scp=84856068489&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84856068489&partnerID=8YFLogxK

U2 - 10.1128/AAC.05381-11

DO - 10.1128/AAC.05381-11

M3 - Article

C2 - 22083486

AN - SCOPUS:84856068489

SN - 0066-4804

VL - 56

SP - 1113

EP - 1115

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 2

ER -

Micafungin concentrations in the plasma and burn eschar of severely burned patients

Abstract

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this