TY - JOUR
T1 - Microfluidic platforms for studies of angiogenesis, cell migration, and cell-cell interactions
T2 - Sixth international bio-fluid mechanics symposium and workshop March 28-30, 2008 Pasadena, California
AU - Chung, Seok
AU - Sudo, Ryo
AU - Vickerman, Vernella
AU - Zervantonakis, Ioannis K.
AU - Kamm, Roger D.
N1 - Funding Information:
The authors would like to express their gratitude to Draper Laboratories (IR&D Project N. DL-H-550151), the National Science Foundation (EFRI-0735997), the NHLBI (EB003805), and the Singapore-MIT Alliance for Research and Technology.
PY - 2010/3
Y1 - 2010/3
N2 - Recent advances in microfluidic technologies have opened the door for creating more realistic in vitro cell culture methods that replicate many aspects of the true in vivo microenvironment. These new designs (i) provide enormous flexibility in controlling the critical biochemical and biomechanical factors that influence cell behavior, (ii) allow for the introduction of multiple cell types in a single system, (iii) provide for the establishment of biochemical gradients in two- or three-dimensional geometries, and (iv) allow for high quality, time-lapse imaging. Here, some of the recent developments are reviewed, with a focus on studies from our own laboratory in three separate areas: angiogenesis, cell migration in the context of tumor cell-endothelial interactions, and liver tissue engineering.
AB - Recent advances in microfluidic technologies have opened the door for creating more realistic in vitro cell culture methods that replicate many aspects of the true in vivo microenvironment. These new designs (i) provide enormous flexibility in controlling the critical biochemical and biomechanical factors that influence cell behavior, (ii) allow for the introduction of multiple cell types in a single system, (iii) provide for the establishment of biochemical gradients in two- or three-dimensional geometries, and (iv) allow for high quality, time-lapse imaging. Here, some of the recent developments are reviewed, with a focus on studies from our own laboratory in three separate areas: angiogenesis, cell migration in the context of tumor cell-endothelial interactions, and liver tissue engineering.
KW - Cancer
KW - Cell culture
KW - Liver
KW - Tissue engineering
KW - Vascular networks
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U2 - 10.1007/s10439-010-9899-3
DO - 10.1007/s10439-010-9899-3
M3 - Article
C2 - 20336839
AN - SCOPUS:77952011208
SN - 0090-6964
VL - 38
SP - 1164
EP - 1177
JO - Annals of Biomedical Engineering
JF - Annals of Biomedical Engineering
IS - 3
ER -
