Micrometer-sized lithium ion-selective microoptodes based on a 'tailed' neutral ionophore and a fluorescent anionic dye

Kazuyoshi Kurihara, Motoichi Ohtsu, Takeo Yoshida, Toshihito Abe, Hideaki Hisamoto, Koji Suzuki

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


The preparation and response features of a micrometer-sized lithium ion-selective optode based on a liquid membrane were examined. The optode membrane was a plasticized poly(vinyl chloride) (PVC)-based copolymer incorporating a lipophilic 14-crown-4 derivative as the neutral lithium ionophore and a dibromofluorescein derivative as the fluorescent anionic dye. The detection mode was a fluorescence change based on the ion-pair extraction/ion exchange principle caused by the fluorescent anionic dye and the lithium ionophore. The 5-μm-sized microoptode was prepared by the micropipette fabrication method and characterized by measuring the optical responses to Li+ concentrations with the time-resolved photon counting method. The microoptode responded to lithium ion concentrations of ~0.5 to ~500mM. The micrometer-sized lithium ion-selective microoptode was successfully obtained when a tailed ionophore was used. The anchor effect of the tailed ionophore was useful for the lithium ion-selective microoptode to resolve leaching of the ionophore, which is a significant problem in a microoptode based on a liquid membrane. This demonstration indicates that other ion-selective microoptodes can be obtained simply by replacing the tailed ionophore. (C) 2001 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)11-18
Number of pages8
JournalAnalytica Chimica Acta
Issue number1
Publication statusPublished - 2001 Jan 1
Externally publishedYes


  • Ion optode
  • Liquid membrane
  • Lithium ion
  • Microoptode
  • Micropipette fabrication
  • Tailed ionophore

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Environmental Chemistry
  • Spectroscopy


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