MicroRNAs in endometrial cancer

Kouji Banno; Megumi Yanokura; Iori Kisu; Wataru Yamagami; Nobuyuki Susumu; Daisuke Aoki

doi:10.1007/s10147-013-0526-9

MicroRNAs in endometrial cancer

Kouji Banno, Megumi Yanokura, Iori Kisu, Wataru Yamagami, Nobuyuki Susumu, Daisuke Aoki

Research output: Contribution to journal › Review article › peer-review

40 Citations (Scopus)

Abstract

MicroRNAs (miRNAs) are small non-coding ribonucleic acids (RNAs) of approximately 22 bp that induce RNA interference with a complementary messenger RNA (mRNA) and act in silencing of mRNA. miRNAs are strongly associated with cancer development and those involved in carcinogenesis are classified into oncogenic miRNAs and tumor suppressor miRNAs (tumor suppressor miRs). Specific miRNAs are expressed in various tissues and changes in regulation of gene expression are thought to cause carcinogenesis. Thus, tissue-specific miRNAs may be biomarkers for cancer diagnosis and prognosis. Approaches to application of miRNAs as cancer therapy are also ongoing, based on the involvement of miRNAs in carcinogenesis. In endometrial cancer, miRNAs are associated with regulation of gene expression, epigenetic dysfunction and carcinogenesis. Thus, miRNAs are likely to have key roles in diagnosis, prognostic prediction, and therapy in endometrial cancer.

Original language	English
Pages (from-to)	186-192
Number of pages	7
Journal	International Journal of Clinical Oncology
Volume	18
Issue number	2
DOIs	https://doi.org/10.1007/s10147-013-0526-9
Publication status	Published - 2013 Apr

Keywords

Endometrial cancer
Epigenetic
MicroRNA
miR-152
miR-34b

ASJC Scopus subject areas

Surgery
Hematology
Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s10147-013-0526-9

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title = "MicroRNAs in endometrial cancer",

abstract = "MicroRNAs (miRNAs) are small non-coding ribonucleic acids (RNAs) of approximately 22 bp that induce RNA interference with a complementary messenger RNA (mRNA) and act in silencing of mRNA. miRNAs are strongly associated with cancer development and those involved in carcinogenesis are classified into oncogenic miRNAs and tumor suppressor miRNAs (tumor suppressor miRs). Specific miRNAs are expressed in various tissues and changes in regulation of gene expression are thought to cause carcinogenesis. Thus, tissue-specific miRNAs may be biomarkers for cancer diagnosis and prognosis. Approaches to application of miRNAs as cancer therapy are also ongoing, based on the involvement of miRNAs in carcinogenesis. In endometrial cancer, miRNAs are associated with regulation of gene expression, epigenetic dysfunction and carcinogenesis. Thus, miRNAs are likely to have key roles in diagnosis, prognostic prediction, and therapy in endometrial cancer.",

keywords = "Endometrial cancer, Epigenetic, MicroRNA, miR-152, miR-34b",

author = "Kouji Banno and Megumi Yanokura and Iori Kisu and Wataru Yamagami and Nobuyuki Susumu and Daisuke Aoki",

note = "Funding Information: The authors gratefully acknowledge grant support from the Japan Society for the Promotion of Science (JSPS) through a Grant-in-Aid for Scientific Research (KAKENHI), a Grant-in-Aid for Scientific Research (B) (22390313), a Grant-in-Aid for Scientific Research (C) (22591866), and a Grant-in-Aid for Young Scientists (B) (24791718); the Ichiro Kanehara Foundation; Kobayashi Foundation for Cancer Research; Keio University Grant-in-Aid for Encouragement of Young Medical Scientists and the Keio University Medical Science Fund through a Research Grant for Life Sciences and Medicine. ",

year = "2013",

month = apr,

doi = "10.1007/s10147-013-0526-9",

language = "English",

volume = "18",

pages = "186--192",

journal = "International Journal of Clinical Oncology",

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AU - Banno, Kouji

AU - Yanokura, Megumi

AU - Kisu, Iori

AU - Yamagami, Wataru

AU - Susumu, Nobuyuki

AU - Aoki, Daisuke

N1 - Funding Information: The authors gratefully acknowledge grant support from the Japan Society for the Promotion of Science (JSPS) through a Grant-in-Aid for Scientific Research (KAKENHI), a Grant-in-Aid for Scientific Research (B) (22390313), a Grant-in-Aid for Scientific Research (C) (22591866), and a Grant-in-Aid for Young Scientists (B) (24791718); the Ichiro Kanehara Foundation; Kobayashi Foundation for Cancer Research; Keio University Grant-in-Aid for Encouragement of Young Medical Scientists and the Keio University Medical Science Fund through a Research Grant for Life Sciences and Medicine.

PY - 2013/4

Y1 - 2013/4

N2 - MicroRNAs (miRNAs) are small non-coding ribonucleic acids (RNAs) of approximately 22 bp that induce RNA interference with a complementary messenger RNA (mRNA) and act in silencing of mRNA. miRNAs are strongly associated with cancer development and those involved in carcinogenesis are classified into oncogenic miRNAs and tumor suppressor miRNAs (tumor suppressor miRs). Specific miRNAs are expressed in various tissues and changes in regulation of gene expression are thought to cause carcinogenesis. Thus, tissue-specific miRNAs may be biomarkers for cancer diagnosis and prognosis. Approaches to application of miRNAs as cancer therapy are also ongoing, based on the involvement of miRNAs in carcinogenesis. In endometrial cancer, miRNAs are associated with regulation of gene expression, epigenetic dysfunction and carcinogenesis. Thus, miRNAs are likely to have key roles in diagnosis, prognostic prediction, and therapy in endometrial cancer.

AB - MicroRNAs (miRNAs) are small non-coding ribonucleic acids (RNAs) of approximately 22 bp that induce RNA interference with a complementary messenger RNA (mRNA) and act in silencing of mRNA. miRNAs are strongly associated with cancer development and those involved in carcinogenesis are classified into oncogenic miRNAs and tumor suppressor miRNAs (tumor suppressor miRs). Specific miRNAs are expressed in various tissues and changes in regulation of gene expression are thought to cause carcinogenesis. Thus, tissue-specific miRNAs may be biomarkers for cancer diagnosis and prognosis. Approaches to application of miRNAs as cancer therapy are also ongoing, based on the involvement of miRNAs in carcinogenesis. In endometrial cancer, miRNAs are associated with regulation of gene expression, epigenetic dysfunction and carcinogenesis. Thus, miRNAs are likely to have key roles in diagnosis, prognostic prediction, and therapy in endometrial cancer.

KW - Endometrial cancer

KW - Epigenetic

KW - MicroRNA

KW - miR-152

KW - miR-34b

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MicroRNAs in endometrial cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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