Midodrine, an Oral Alpha-1 Adrenoreceptor Agonist, Successfully Treated Refractory Congenital Chylous Pleural Effusion and Ascites in a Neonate

Satoshi Tamaoka; Asami Osada; Takane Kin; Takeshi Arimitsu; Mariko Hida

doi:10.1016/j.chest.2020.10.071

Midodrine, an Oral Alpha-1 Adrenoreceptor Agonist, Successfully Treated Refractory Congenital Chylous Pleural Effusion and Ascites in a Neonate

Satoshi Tamaoka, Asami Osada, Takane Kin, Takeshi Arimitsu, Mariko Hida

Department of Pediatrics

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

A trisomy 21 neonate presented with congenital chylous pleural effusion and ascites that was refractory to conventional pharmacotherapy. Midodrine, an oral alpha-1-adrenoreceptor agonist, achieved remission of chylous effusion without any adverse effects. To the best of our knowledge, this is the first neonatal case of successful management of congenital chylous pleural effusion and ascites with midodrine.

Original language	English
Pages (from-to)	e189-e191
Journal	Chest
Volume	159
Issue number	4
DOIs	https://doi.org/10.1016/j.chest.2020.10.071
Publication status	Published - 2021 Apr

Keywords

congenital chylothorax
congenital chylous ascites
midodrine
neonate
trisomy 21

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine
Critical Care and Intensive Care Medicine
Cardiology and Cardiovascular Medicine

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10.1016/j.chest.2020.10.071

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title = "Midodrine, an Oral Alpha-1 Adrenoreceptor Agonist, Successfully Treated Refractory Congenital Chylous Pleural Effusion and Ascites in a Neonate",

abstract = "A trisomy 21 neonate presented with congenital chylous pleural effusion and ascites that was refractory to conventional pharmacotherapy. Midodrine, an oral alpha-1-adrenoreceptor agonist, achieved remission of chylous effusion without any adverse effects. To the best of our knowledge, this is the first neonatal case of successful management of congenital chylous pleural effusion and ascites with midodrine.",

keywords = "congenital chylothorax, congenital chylous ascites, midodrine, neonate, trisomy 21",

author = "Satoshi Tamaoka and Asami Osada and Takane Kin and Takeshi Arimitsu and Mariko Hida",

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AU - Tamaoka, Satoshi

AU - Osada, Asami

AU - Kin, Takane

AU - Arimitsu, Takeshi

AU - Hida, Mariko

PY - 2021/4

Y1 - 2021/4

N2 - A trisomy 21 neonate presented with congenital chylous pleural effusion and ascites that was refractory to conventional pharmacotherapy. Midodrine, an oral alpha-1-adrenoreceptor agonist, achieved remission of chylous effusion without any adverse effects. To the best of our knowledge, this is the first neonatal case of successful management of congenital chylous pleural effusion and ascites with midodrine.

AB - A trisomy 21 neonate presented with congenital chylous pleural effusion and ascites that was refractory to conventional pharmacotherapy. Midodrine, an oral alpha-1-adrenoreceptor agonist, achieved remission of chylous effusion without any adverse effects. To the best of our knowledge, this is the first neonatal case of successful management of congenital chylous pleural effusion and ascites with midodrine.

KW - congenital chylothorax

KW - congenital chylous ascites

KW - midodrine

KW - neonate

KW - trisomy 21

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Midodrine, an Oral Alpha-1 Adrenoreceptor Agonist, Successfully Treated Refractory Congenital Chylous Pleural Effusion and Ascites in a Neonate

Abstract

Keywords

ASJC Scopus subject areas

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