Migracins A and B, new inhibitors of cancer cell migration, produced by Streptomyces sp.

Yuhei Arai; Hironobu Iinuma; Yoko Ikeda; Masayuki Igarashi; Masaki Hatano; Naoko Kinoshita; Tamami Ukaji; Siro Simizu; Kazuo Umezawa

doi:10.1038/ja.2012.112

Migracins A and B, new inhibitors of cancer cell migration, produced by Streptomyces sp.

Yuhei Arai, Hironobu Iinuma, Yoko Ikeda, Masayuki Igarashi, Masaki Hatano, Naoko Kinoshita, Tamami Ukaji, Siro Simizu, Kazuo Umezawa

Department of Applied Chemistry

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

In the course of screening for breast cancer cell migration inhibitors, we isolated two novel compounds, migracins A and B from the culture broth of Streptomyces sp. MI264-NF2. Their structures are related to those of luminacins previously isolated from Streptomyces. Migracins A and B inhibited breast cancer cell migration, monitored by wound healing assay with IC 50 values of 1.31 and 1.99 μg ml -1, respectively, in human breast carcinoma MDA-MB-231 cells without showing any cytotoxicity. Migracins also inhibited the migration of human lung adenocarcinoma A549 cells and human fibrosarcoma HT-1080 cells. Therefore, migracins may become new cancer metastasis inhibitors.

Original language	English
Pages (from-to)	225-230
Number of pages	6
Journal	Journal of Antibiotics
Volume	66
Issue number	4
DOIs	https://doi.org/10.1038/ja.2012.112
Publication status	Published - 2013 Apr

Keywords

Breast carcinoma
Cancer cell migration
Luminacin
Migracin
Streptomyces sp.

ASJC Scopus subject areas

Pharmacology
Drug Discovery

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/ja.2012.112

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title = "Migracins A and B, new inhibitors of cancer cell migration, produced by Streptomyces sp.",

abstract = "In the course of screening for breast cancer cell migration inhibitors, we isolated two novel compounds, migracins A and B from the culture broth of Streptomyces sp. MI264-NF2. Their structures are related to those of luminacins previously isolated from Streptomyces. Migracins A and B inhibited breast cancer cell migration, monitored by wound healing assay with IC 50 values of 1.31 and 1.99 μg ml -1, respectively, in human breast carcinoma MDA-MB-231 cells without showing any cytotoxicity. Migracins also inhibited the migration of human lung adenocarcinoma A549 cells and human fibrosarcoma HT-1080 cells. Therefore, migracins may become new cancer metastasis inhibitors.",

keywords = "Breast carcinoma, Cancer cell migration, Luminacin, Migracin, Streptomyces sp.",

author = "Yuhei Arai and Hironobu Iinuma and Yoko Ikeda and Masayuki Igarashi and Masaki Hatano and Naoko Kinoshita and Tamami Ukaji and Siro Simizu and Kazuo Umezawa",

note = "Funding Information: We wish to thank Dr Shinichi Kondo, Bioscience Associates, Tokyo, for valuable suggestions. The work described in this report was supported in part by grants from the programs Grants-in-Aid for Scientific Research (B) and the Keio Gijuku Fukuzawa Memorial Fund for the Advancement of Education and Research. This work was also supported in part by MEXT-Supported Program for the Strategic Research Foundation at Private Universities, Aichi Medical University 2011-2015 (S1101027).",

year = "2013",

month = apr,

doi = "10.1038/ja.2012.112",

language = "English",

volume = "66",

pages = "225--230",

journal = "Journal of Antibiotics",

issn = "0021-8820",

publisher = "Japan Antibiotics Research Association",

number = "4",

}

TY - JOUR

T1 - Migracins A and B, new inhibitors of cancer cell migration, produced by Streptomyces sp.

AU - Arai, Yuhei

AU - Iinuma, Hironobu

AU - Ikeda, Yoko

AU - Igarashi, Masayuki

AU - Hatano, Masaki

AU - Kinoshita, Naoko

AU - Ukaji, Tamami

AU - Simizu, Siro

AU - Umezawa, Kazuo

N1 - Funding Information: We wish to thank Dr Shinichi Kondo, Bioscience Associates, Tokyo, for valuable suggestions. The work described in this report was supported in part by grants from the programs Grants-in-Aid for Scientific Research (B) and the Keio Gijuku Fukuzawa Memorial Fund for the Advancement of Education and Research. This work was also supported in part by MEXT-Supported Program for the Strategic Research Foundation at Private Universities, Aichi Medical University 2011-2015 (S1101027).

PY - 2013/4

Y1 - 2013/4

N2 - In the course of screening for breast cancer cell migration inhibitors, we isolated two novel compounds, migracins A and B from the culture broth of Streptomyces sp. MI264-NF2. Their structures are related to those of luminacins previously isolated from Streptomyces. Migracins A and B inhibited breast cancer cell migration, monitored by wound healing assay with IC 50 values of 1.31 and 1.99 μg ml -1, respectively, in human breast carcinoma MDA-MB-231 cells without showing any cytotoxicity. Migracins also inhibited the migration of human lung adenocarcinoma A549 cells and human fibrosarcoma HT-1080 cells. Therefore, migracins may become new cancer metastasis inhibitors.

AB - In the course of screening for breast cancer cell migration inhibitors, we isolated two novel compounds, migracins A and B from the culture broth of Streptomyces sp. MI264-NF2. Their structures are related to those of luminacins previously isolated from Streptomyces. Migracins A and B inhibited breast cancer cell migration, monitored by wound healing assay with IC 50 values of 1.31 and 1.99 μg ml -1, respectively, in human breast carcinoma MDA-MB-231 cells without showing any cytotoxicity. Migracins also inhibited the migration of human lung adenocarcinoma A549 cells and human fibrosarcoma HT-1080 cells. Therefore, migracins may become new cancer metastasis inhibitors.

KW - Breast carcinoma

KW - Cancer cell migration

KW - Luminacin

KW - Migracin

KW - Streptomyces sp.

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SN - 0021-8820

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JO - Journal of Antibiotics

JF - Journal of Antibiotics

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Migracins A and B, new inhibitors of cancer cell migration, produced by Streptomyces sp.

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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