Millimeter-Sized Neural Building Blocks for 3D Heterogeneous Neural Network Assembly

Midori Kato-Negishi, Yuya Morimoto, Hiroaki Onoe, Shoji Takeuchi

Research output: Contribution to journalArticlepeer-review

68 Citations (Scopus)


A millimeter-sized neural building block (NBB) shows high versatility to form a 3D heterogeneous neural component. A millimeter-sized 3D neural network between heterogeneous neural tissues is established, and an efficient technique is then developed to observe the spatiotemporal metrological changes of single neuron in the NBB. This technique allows the visualization of axonal extension, dendritic branching, and morphological changes of presynaptic components and synapses in real time.

Original languageEnglish
Pages (from-to)1564-1570
Number of pages7
JournalAdvanced Healthcare Materials
Issue number12
Publication statusPublished - 2013 Dec
Externally publishedYes


  • Assembly
  • Cortex
  • Hippocampus
  • Neural network
  • Three-dimensional neural tissue

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Pharmaceutical Science


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