Millimeter-Sized Neural Building Blocks for 3D Heterogeneous Neural Network Assembly

Midori Kato-Negishi; Yuya Morimoto; Hiroaki Onoe; Shoji Takeuchi

doi:10.1002/adhm.201300052

Millimeter-Sized Neural Building Blocks for 3D Heterogeneous Neural Network Assembly

Midori Kato-Negishi, Yuya Morimoto, Hiroaki Onoe, Shoji Takeuchi

Research output: Contribution to journal › Article › peer-review

68 Citations (Scopus)

Abstract

A millimeter-sized neural building block (NBB) shows high versatility to form a 3D heterogeneous neural component. A millimeter-sized 3D neural network between heterogeneous neural tissues is established, and an efficient technique is then developed to observe the spatiotemporal metrological changes of single neuron in the NBB. This technique allows the visualization of axonal extension, dendritic branching, and morphological changes of presynaptic components and synapses in real time.

Original language	English
Pages (from-to)	1564-1570
Number of pages	7
Journal	Advanced Healthcare Materials
Volume	2
Issue number	12
DOIs	https://doi.org/10.1002/adhm.201300052
Publication status	Published - 2013 Dec
Externally published	Yes

Keywords

Assembly
Cortex
Hippocampus
Neural network
Three-dimensional neural tissue

ASJC Scopus subject areas

Biomaterials
Biomedical Engineering
Pharmaceutical Science

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10.1002/adhm.201300052

Cite this

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AU - Onoe, Hiroaki

AU - Takeuchi, Shoji

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AB - A millimeter-sized neural building block (NBB) shows high versatility to form a 3D heterogeneous neural component. A millimeter-sized 3D neural network between heterogeneous neural tissues is established, and an efficient technique is then developed to observe the spatiotemporal metrological changes of single neuron in the NBB. This technique allows the visualization of axonal extension, dendritic branching, and morphological changes of presynaptic components and synapses in real time.

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KW - Hippocampus

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KW - Three-dimensional neural tissue

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Millimeter-Sized Neural Building Blocks for 3D Heterogeneous Neural Network Assembly

Abstract

Keywords

ASJC Scopus subject areas

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