TY - JOUR
T1 - Mindfulness-Based Cognitive Therapy for Psychological Distress, Fear of Cancer Recurrence, Fatigue, Spiritual Well-Being, and Quality of Life in Patients With Breast Cancer—A Randomized Controlled Trial
AU - Park, Sunre
AU - Sato, Yasuko
AU - Takita, Yuka
AU - Tamura, Noriko
AU - Ninomiya, Akira
AU - Kosugi, Teppei
AU - Sado, Mitsuhiro
AU - Nakagawa, Atsuo
AU - Takahashi, Maiko
AU - Hayashida, Tetsu
AU - Fujisawa, Daisuke
N1 - Funding Information:
The authors are grateful to all the patients who participated in this trial. They thank Prof. Hiromitsu Jinno (Teikyo University) for referring patients to the trial, Prof. Yasunori Sato (Keio University Hospital Clinical and Translational Research Center) for his comments on the statistical analyses, and Prof. Yuko Takeda (Keio University Faculty of Nursing and Medical Care) for her mentorship. This study was supported by Keio Gijuku Academic Development Funds and Japan Society for the Promotion of Science KAKENHI (grant number: JP15K09875 ). The authors declare no conflicts of interest.
Funding Information:
The authors are grateful to all the patients who participated in this trial. They thank Prof. Hiromitsu Jinno (Teikyo University) for referring patients to the trial, Prof. Yasunori Sato (Keio University Hospital Clinical and Translational Research Center) for his comments on the statistical analyses, and Prof. Yuko Takeda (Keio University Faculty of Nursing and Medical Care) for her mentorship. This study was supported by Keio Gijuku Academic Development Funds and Japan Society for the Promotion of Science KAKENHI (grant number: JP15K09875). The authors declare no conflicts of interest. Data availability: The data of this study are available from the corresponding author on reasonable request. Ethical approval: This study was approved by the Institutional Review Board of Keio University School of Medicine and was registered in the Japanese Clinical Trial Registry (registry ID: UMIN000016142).
Publisher Copyright:
© 2020 American Academy of Hospice and Palliative Medicine
PY - 2020/8
Y1 - 2020/8
N2 - Context: Mindfulness-based interventions have been receiving growing attention in cancer care. Objectives: The purpose of this randomized controlled trial is to examine the effectiveness of mindfulness-based cognitive therapy (MBCT) for psychological distress (anxiety and depression), fear of cancer recurrence (FCR), fatigue, spiritual well-being, and quality of life (QOL) in Japanese ambulatory patients with Stage I–III breast cancer. Methods: A total of 74 patients were randomly assigned to either an eight-week MBCT intervention group (n = 38) or a wait-list control group (n = 36). The primary outcome was psychological distress, measured on Hospital Anxiety and Depression Scale. The secondary outcomes were FCR (Concerns About Recurrence Scale—overall anxiety subscale), fatigue (Brief Fatigue Inventory), spiritual well-being (Functional Assessment of Chronic Illness Therapy—Spiritual), QOL (Functional Assessment of Cancer Therapy—General), and mindfulness skills (Five Facet Mindfulness Questionnaire). The participants were assessed at baseline (T0), Week 8 (T1), and Week 12 (T2). The results were analyzed using a intention-to-treat linear mixed model. Results: The participants in the MBCT group experienced significantly better outcomes in their psychological distress (Cohen's d = 1.17; P < 0.001), FCR (d = 0.43; P < 0.05), fatigue (d = 0.66; P < 0.01), spiritual well-being (d = 0.98; P < 0.001), and QOL (d = 0.79; P < 0.001) compared with the control group. The difference remained significant at T2 (four weeks after completion of the intervention). Conclusion: MBCT was demonstrated to improve well-being that encompasses psychological, physical, and spiritual domains in Japanese patients with nonmetastatic breast cancer. The favorable effect was maintained up to four weeks after the completion of the intervention.
AB - Context: Mindfulness-based interventions have been receiving growing attention in cancer care. Objectives: The purpose of this randomized controlled trial is to examine the effectiveness of mindfulness-based cognitive therapy (MBCT) for psychological distress (anxiety and depression), fear of cancer recurrence (FCR), fatigue, spiritual well-being, and quality of life (QOL) in Japanese ambulatory patients with Stage I–III breast cancer. Methods: A total of 74 patients were randomly assigned to either an eight-week MBCT intervention group (n = 38) or a wait-list control group (n = 36). The primary outcome was psychological distress, measured on Hospital Anxiety and Depression Scale. The secondary outcomes were FCR (Concerns About Recurrence Scale—overall anxiety subscale), fatigue (Brief Fatigue Inventory), spiritual well-being (Functional Assessment of Chronic Illness Therapy—Spiritual), QOL (Functional Assessment of Cancer Therapy—General), and mindfulness skills (Five Facet Mindfulness Questionnaire). The participants were assessed at baseline (T0), Week 8 (T1), and Week 12 (T2). The results were analyzed using a intention-to-treat linear mixed model. Results: The participants in the MBCT group experienced significantly better outcomes in their psychological distress (Cohen's d = 1.17; P < 0.001), FCR (d = 0.43; P < 0.05), fatigue (d = 0.66; P < 0.01), spiritual well-being (d = 0.98; P < 0.001), and QOL (d = 0.79; P < 0.001) compared with the control group. The difference remained significant at T2 (four weeks after completion of the intervention). Conclusion: MBCT was demonstrated to improve well-being that encompasses psychological, physical, and spiritual domains in Japanese patients with nonmetastatic breast cancer. The favorable effect was maintained up to four weeks after the completion of the intervention.
KW - Breast cancer
KW - fatigue
KW - fear of cancer recurrence
KW - mindfulness
KW - psychological distress
KW - quality of life
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UR - http://www.scopus.com/inward/citedby.url?scp=85081987278&partnerID=8YFLogxK
U2 - 10.1016/j.jpainsymman.2020.02.017
DO - 10.1016/j.jpainsymman.2020.02.017
M3 - Article
C2 - 32105790
AN - SCOPUS:85081987278
SN - 0885-3924
VL - 60
SP - 381
EP - 389
JO - Journal of Pain and Symptom Management
JF - Journal of Pain and Symptom Management
IS - 2
ER -
