Misprocessed tRNA response targets piRNA clusters

Soichiro Yamanaka, Haruhiko Siomi

Research output: Contribution to journalShort surveypeer-review

5 Citations (Scopus)


Germline PIWI-interacting RNA (piRNA) clusters have a characteristic transcriptional status; although they do not have their own promoters, both genomic strands are transcribed, while splicing and 3' processing signals are neglected. How this transcription is maintained remains unknown. Molla-Herman et al (2015) discovered that mutations in a tRNA processing factor cause the loss of transcription at some piRNA clusters, leading to sterility in Drosophila melanogaster. This defect in piRNA cluster transcription is restored by mutations in genes required for the DNA damage checkpoint or replication.

Original languageEnglish
Pages (from-to)2988-2989
Number of pages2
JournalEMBO Journal
Issue number24
Publication statusPublished - 2015 Dec 14

ASJC Scopus subject areas

  • General Neuroscience
  • Molecular Biology
  • General Biochemistry,Genetics and Molecular Biology
  • General Immunology and Microbiology


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