Missense mutations of the BRAF gene in human lung adenocarcinoma

Katsuhiko Naoki, Tzu Hsiu Chen, William G. Richards, David J. Sugarbaker, Matthew Meyerson

Research output: Contribution to journalArticlepeer-review

271 Citations (Scopus)


Mutations of the BRAF protein serine/threonine kinase gene have recently been identified in a variety of human cancers, most notably melanomas. We sought to determine the frequency of BRAF mutations in human lung cancer pathogenesis. Analysis of BRAF sequence from 127 primary human lung adenocarcinomas revealed mutations in two tumor specimens, one in exon 11 (G465V), and a second in exon 15 (L596R). These specimens belong to the same adenocarcinoma subgroup as defined by clustering of gene expression data. BRAF may provide a target for anticancer chemotherapy in a subset of lung adenocarcinoma patients.

Original languageEnglish
Pages (from-to)7001-7003
Number of pages3
JournalCancer Research
Issue number23
Publication statusPublished - 2002 Dec 1

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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