Modification and functionalization of hydrogel microspheres

Haruma Kawaguchi, Keiji Fujimoto, Yoshiyuki Nakazawa, Mami Sakagawa, Yasushi Ariyoshi, Miwako Shidara, Hitoshi Okazaki, Yukio Ebisawa

Research output: Contribution to journalArticlepeer-review

39 Citations (Scopus)


Acrylamide (AAm)-methacrylic acid (MAc)-methylenebisacrylamide (MBAAm) terpolymer microspheres and AAm-MAc-MBAAm-nitrophenyl acrylate (NPA) quaterpolymer microspheres with high monodispersity were prepared by precipitation polymerization in alcohol. The former were modified into composite microspheres containing hydrophobic domains or magnetite nanospheres. The active ester in the quaterpolymer microspheres was allowed to undergo hydrolysis or aminolysis to prepare novel microspheres such as highly negative, amphoteric, hydrophobic or bioconjugate microspheres.

Original languageEnglish
Pages (from-to)147-154
Number of pages8
JournalColloids and Surfaces A: Physicochemical and Engineering Aspects
Publication statusPublished - 1996 Apr 20


  • amphoteric particle
  • composite particle
  • hydrogel
  • microsphere
  • modification

ASJC Scopus subject areas

  • Surfaces and Interfaces
  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry


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