Modulation of immune responses by DNA damage signaling

Yuki Uchihara, Tiara Bunga Mayang Permata, Hiro Sato, Atsushi Shibata

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


An accumulation of evidence indicates the importance of DNA damage signaling in modulating immune responses. Indeed, understanding the mechanism that underlies signal transduction originating from DNA damage is vital to overcoming refractory cancer, particularly when cancer immune therapy is applied in combination with DNA damage-dependent radio/chemotherapy. In addition, immune-associated responses to such signals can aggravate the symptoms of infections, allergies, autoimmune disease, and aging. In this review, we discuss how cells transduce signals, triggered by DNA damage, from their origins to neighboring cells and how this affects immune and inflammatory responses.

Original languageEnglish
Article number103135
JournalDNA Repair
Publication statusPublished - 2021 Aug
Externally publishedYes


  • Cancer therapy
  • DNA damage signaling
  • Immune crosstalk
  • Immune-associated disease
  • Inflammation

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology


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