TY - JOUR
T1 - Modulation of mu rhythm desynchronization during motor imagery by transcranial direct current stimulation
AU - Matsumoto, Jun
AU - Fujiwara, Toshiyuki
AU - Takahashi, Osamu
AU - Liu, Meigen
AU - Kimura, Akio
AU - Ushiba, Junichi
N1 - Funding Information:
This study was partially supported by the Strategic Research Program for Brain Sciences (SRPBS) and Grant-in-Aid for Scientific Research (C) (20500465) from the Ministry of Education, Culture, Sports, Science and Technology Japan.
PY - 2010
Y1 - 2010
N2 - Background. The mu event-related desynchronization (ERD) is supposed to reflect motor preparation and appear during motor imagery. The aim of this study is to examine the modulation of ERD with transcranial direct current stimulation (tDCS). Methods. Six healthy subjects were asked to imagine their right hand grasping something after receiving a visual cue. Electroencephalograms (EEGs) were recorded near the left M1. ERD of the mu rhythm (mu ERD) by right hand motor imagery was measured. tDCS (10 min, 1 mA) was used to modulate the cortical excitability of M1. Anodal, cathodal, and sham tDCS were tested in each subject with a randomized sequence on different days. Each condition was separated from the preceding one by more than 1 week in the same subject. Before and after tDCS, mu ERD was assessed. The motor thresholds (MT) of the left M1 were also measured with transcranial magnetic stimulation. Results. Mu ERD significantly increased after anodal stimulation, whereas it significantly decreased after cathodal stimulation. There was a significant correlation between mu ERD and MT. Conclusions. Opposing effects on mu ERD based on the orientation of the stimulation suggest that mu ERD is affected by cortical excitability.
AB - Background. The mu event-related desynchronization (ERD) is supposed to reflect motor preparation and appear during motor imagery. The aim of this study is to examine the modulation of ERD with transcranial direct current stimulation (tDCS). Methods. Six healthy subjects were asked to imagine their right hand grasping something after receiving a visual cue. Electroencephalograms (EEGs) were recorded near the left M1. ERD of the mu rhythm (mu ERD) by right hand motor imagery was measured. tDCS (10 min, 1 mA) was used to modulate the cortical excitability of M1. Anodal, cathodal, and sham tDCS were tested in each subject with a randomized sequence on different days. Each condition was separated from the preceding one by more than 1 week in the same subject. Before and after tDCS, mu ERD was assessed. The motor thresholds (MT) of the left M1 were also measured with transcranial magnetic stimulation. Results. Mu ERD significantly increased after anodal stimulation, whereas it significantly decreased after cathodal stimulation. There was a significant correlation between mu ERD and MT. Conclusions. Opposing effects on mu ERD based on the orientation of the stimulation suggest that mu ERD is affected by cortical excitability.
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U2 - 10.1186/1743-0003-7-27
DO - 10.1186/1743-0003-7-27
M3 - Article
C2 - 20540721
AN - SCOPUS:77953301889
SN - 1743-0003
VL - 7
JO - Journal of neuroengineering and rehabilitation
JF - Journal of neuroengineering and rehabilitation
IS - 1
M1 - 27
ER -