Molecular alterations in Barrett's esophagus and adenocarcinoma

S. Ozawa, N. Ando, Y. Kitagawa, M. Ueda, M. Kitajima

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)


Patients with Barrett's columnar-lined esophagus are at increased risk of developing esophageal adenocarcinoma, the incidence of which has increased rapidly especially in the USA. Although the number of patients with Barrett's adenocarcinoma is fewer in Japan than in the USA, all gastroenterologist should know its multistep carcinogenic process. Tumor suppressor genes (p53, p16), oncogenes (c-erbB-2, H-ras, K-ras, cyclin D1, src), and growth factor/receptor (TGF-alpha, EGFR) seem to cause the malignant transformation of Barrett's esophagus. Because detection of these molecular alterations is feasible, more accurate diagnosis of Barrett's esophageal biopsy specimens should be made by adding the molecular examination to the conventional pathologic examination.

Original languageEnglish
Pages (from-to)235-239
Number of pages5
JournalNippon Geka Gakkai zasshi
Issue number3
Publication statusPublished - 1999 Mar

ASJC Scopus subject areas

  • General Medicine


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