Molecular approaches and modern clinical strategies for the management of Helicobacter pylori infection in Japan

Hidekazu Suzuki, Toshihiro Nishizawa, Hitoshi Tsugawa, Toshifumi Hibi

Research output: Contribution to journalReview articlepeer-review

10 Citations (Scopus)

Abstract

Thirty years have passed since Warren and Marshall's discovery of Helicobacter pylori (H. pylori). Since then, not only peptic ulcer diseases and chronic gastritis but also non-cardia gastric cancers have been recognized as diseases originating from H. pylori infection. Several combination therapies consisting of multiple antibiotics have been developed as first- or second-line regimens to eradicate H. pylori infection. Our extensive experience in the field of anti-H. pylori medicine suggests that clinicians should consider a possible role for unidentified, invisible pathogens to elucidate the pathogenesis and improve the treatment of refractory diseases of unknown etiology.

Original languageEnglish
Pages (from-to)109-119
Number of pages11
JournalKeio Journal of Medicine
Volume61
Issue number4
DOIs
Publication statusPublished - 2012 Dec

Keywords

  • CagA
  • Diagnosis
  • Eradication
  • Helicobacter pylori
  • Indication

ASJC Scopus subject areas

  • General Medicine

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