Molecular basis of chemical chaperone effects of N-octyl-β-valienamine on human β-glucosidase in low/neutral pH conditions

Engineering & Materials Science

• Glucosidases 83%
• Enzymes 52%
• Hydrogen bonds 47%
• Hydrolases 43%
• Protonation 42%
• Free energy 41%
• Enzyme activity 18%
• Chemical compounds 16%
• Molecular dynamics 12%
• Atoms 11%
• Acids 10%
• Catalysts 9%
• Computer simulation 6%

Medicine & Life Sciences

• valienamine 100%
• Glucosidases 69%
• Hydrogen Bonding 23%
• Enzymes 18%
• Hydrolases 15%
• Pharmacologic Actions 9%
• Molecular Dynamics Simulation 7%
• Lysosomes 6%
• Catalytic Domain 5%
• Acids 4%
• Therapeutics 2%

Chemical Compounds

• pH Value 19%
• Gibbs Free Energy 14%
• Hydrogen Bond 11%
• Dissociation 9%
• Chemical Compound 7%
• pKa 6%
• Acidic Condition 6%
• Enzyme Activity 5%
• Molecular Dynamics 4%
• Simulation 4%
• Acid 2%